Abstract
The polymerase chain reaction (PCR) method was used to determine the presence of Epstein-Barr virus sequences in seven cases of pulmonary lymphoid interstitial pneumonia not associated with HIV infection. Evidence of Epstein-Barr virus genome was found in three of six cases in which beta-globin gene, used as an internal control for the integrity and amplifiability of the tissue DNA, could be detected. These results suggest that Epstein-Barr virus infection is not always required for the development of lymphoid interstitial pneumonia.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Base Sequence
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DNA Primers / chemistry
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Female
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Follow-Up Studies
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HIV Infections
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Herpesviridae Infections / microbiology*
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Herpesvirus 4, Human / genetics*
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Herpesvirus 4, Human / isolation & purification
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Humans
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Lung Diseases, Interstitial / microbiology*
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Lymphoproliferative Disorders / microbiology*
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Male
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Middle Aged
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Molecular Sequence Data
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Oligonucleotide Probes / chemistry
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Polymerase Chain Reaction
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Tumor Virus Infections / microbiology*
Substances
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DNA Primers
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Oligonucleotide Probes