Respiratory virus infections have pronounced and long-lasting effects on patients with cystic fibrosis (CF), resulting in significant declines in FVC, FEV(1) and Shwachman score, significantly increasing both the frequency and duration of hospitalisation. Deleterious effects on patients with CF have been reported for most viruses studied but the effects of respiratory syncytial virus and influenza appear the greatest. There is circumstantial evidence that respiratory virus infections may facilitate bacterial infections, particularly Pseudomonas aeruginosa.