HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

Cell. 2001 Oct 5;107(1):1-3. doi: 10.1016/s0092-8674(01)00518-9.

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins*
  • Cell Hypoxia*
  • Cell Nucleus / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation / physiology
  • Helminth Proteins / metabolism
  • Homeostasis
  • Humans
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Oxygen / metabolism*
  • Procollagen-Proline Dioxygenase / metabolism*
  • Signal Transduction / physiology*
  • Transcription Factors*

Substances

  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Egl-9 protein, C elegans
  • HIF1A protein, human
  • Helminth Proteins
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins
  • Transcription Factors
  • Procollagen-Proline Dioxygenase
  • Oxygen