Abstract
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
MeSH terms
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Animals
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Caenorhabditis elegans Proteins*
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Cell Hypoxia*
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Cell Nucleus / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Gene Expression Regulation / physiology
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Helminth Proteins / metabolism
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Homeostasis
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Humans
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Oxygen / metabolism*
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Procollagen-Proline Dioxygenase / metabolism*
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Signal Transduction / physiology*
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Transcription Factors*
Substances
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Caenorhabditis elegans Proteins
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DNA-Binding Proteins
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Egl-9 protein, C elegans
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HIF1A protein, human
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Helminth Proteins
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Transcription Factors
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Procollagen-Proline Dioxygenase
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Oxygen