Abstract
The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.
Publication types
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Clinical Trial
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Comparative Study
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Letter
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aerosol Propellants*
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Androstadienes / pharmacokinetics*
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Anti-Asthmatic Agents / pharmacokinetics*
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Biological Availability
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Chlorofluorocarbons*
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Dose-Response Relationship, Drug
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Fluticasone
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Humans
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Hydrocarbons, Fluorinated*
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Hydrocortisone / urine
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Lung / drug effects
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Lung / metabolism
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Single-Blind Method
Substances
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Aerosol Propellants
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Androstadienes
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Anti-Asthmatic Agents
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Chlorofluorocarbons
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Hydrocarbons, Fluorinated
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Fluticasone
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apaflurane
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Hydrocortisone