Skip to main content
Home / The International Journal of Tuberculosis and Lung Disease, Volume 20, Number 7

Treatment regimens for rifampicin-resistant tuberculosis: highlighting a research gap

Buy Article:

$34.78 + tax (Refund Policy)

Treatment guidance for non-multidrug-resistant (MDR) rifampicin-resistant (RMP-R) tuberculosis (TB) is variable. We aimed to undertake a systematic review and meta-analysis of the randomised controlled trial (RCT) data behind such guidelines to identify the most efficacious treatment regimens. Ovid MEDLINE, the Web of Science and EMBASE were mined using search terms for TB, drug therapy and RCTs. Despite 12 604 records being retrieved, only three studies reported treatment outcomes by regimen for patients with non-MDR RMP-R disease, preventing meta-analysis. Our systematic review highlights a substantial gap in the literature regarding evidence-based treatment regimens for RMP-R TB.

Keywords: monoresistance; randomised controlled trials; systematic review

Document Type: Research Article

Affiliations: 1: Research Department of Infection and Population Health 2: Research Department of Infection and Population Health, University College London (UCL) CoMPLEX, Faculty of Mathematics and Physical Sciences 3: UCL Respiratory, Division of Medicine, UCL, London, Royal Free London National Health Service Foundation Trust, London 4: Statistics, Modelling and Economics Department, Public Health England, London 5: Research Department of Infection and Population Health, Medical Research Council Clinical Trials Unit, UCL, London, UK

Publication date: 01 July 2016

More about this publication?

  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites

Share Content

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content