Original ContributionPhotodynamic Therapy for Patients with Advanced Non–Small-Cell Carcinoma of the Lung
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Cited by (28)
Photodynamic therapy for lung cancer and malignant pleural mesothelioma
2014, Seminars in OncologyCitation Excerpt :PDT also can serve as a management tool for hemoptysis by causing thrombosis and controlling small vessel bleeding.24 In fact, resolution of acute bleeding was achieved in 70% of patients treated at the University of California, Irvine with stage III–IV obstructive inoperable NSCLC with hemoptysis, dyspnea, and airway obstruction.25 Similar excellent control of hemoptysis was achieved with PDT in a prospective study in Austria.26
Endobronchial Ablative Therapies
2013, Clinics in Chest MedicineCitation Excerpt :The photosensitization agent is taken up by actively metabolizing cells and to a higher degree by malignant tissues.22,23 A standard bronchoscope is then used to survey the airway and to advance the light probe into position.22,23 Once in position, the light probe is activated and emits light at a specific frequency to activate the photosensitizing agent.22,23
The effect of Radachlorin<sup>®</sup> PDT in advanced NSCLC: A pilot study
2013, Photodiagnosis and Photodynamic TherapySurgical and Endoscopic Palliation of Advanced Lung Cancer
2011, Surgical Oncology Clinics of North AmericaCitation Excerpt :Repeat treatment can also be performed after debridement but needs to be performed within the prescribed time (within 7 days of Photofrin injection) to achieve additional tumoricidal effect. Several studies have confirmed the efficacy and safety of PDT procedures for cancer, and, in those with advanced-stage cancer and endoluminal bronchial obstruction, PDT is capable of providing significant palliative improvement and may have a more durable benefit than mechanical debridement or laser resection because of its wider radial effect of tumor necrosis, which may delay tumor regrowth and obstruction.8 In many cases of NSCLC, patients with inoperable cancer are referred for PDT following recurrence of tumor after chemotherapy/radiotherapy.9
Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis
2010, European Journal of PharmacologyCitation Excerpt :Photodynamic therapy is an effective therapy for local malignant tumors and involves a tumor-localizing photosensitizing agent, light and molecular oxygen (Castano et al., 2006; Morton et al., 2002). Recently, photodynamic therapy has been a treatment option for lung cancer that involves the administration of a photosensitizing agent and fiberoptic bronchoscope, which was used to deliver light to tumor tissue that has retained the agent (Jones et al., 2001; McCaughan, 1999). Aloe-emodin is an anthraquinone derivative similar to hypericin in structure, the third generation photosensitizer.
Photodynamic Laser Therapy for Lesions in the Airway
2010, Annals of Thoracic Surgery