Abstract
Chronic obstructive pulmonary disease is a major cause of morbidity and mortality worldwide. The mechanisms by which cigarette smoke leads to the irreversible dilatation and destruction of terminal airspaces of the lung are being unravelled largely as a result of the explosion of studies in animals. At the forefront of this has been the use of genetically manipulated mice, and the evolution and understanding of different models of emphysema. This review will summarise the current models of emphysema.
Keywords: Animal models, chronic obstructive pulmonary disease, emphysema, pathogenesis, proteinase, cigarette smoke, genetic engineering
Current Drug Targets - Inflammation & Allergy
Title: Animal Models of Pulmonary Emphysema
Volume: 4 Issue: 6
Author(s): Ravi Mahadeva and Steven D. Shapiro
Affiliation:
Keywords: Animal models, chronic obstructive pulmonary disease, emphysema, pathogenesis, proteinase, cigarette smoke, genetic engineering
Abstract: Chronic obstructive pulmonary disease is a major cause of morbidity and mortality worldwide. The mechanisms by which cigarette smoke leads to the irreversible dilatation and destruction of terminal airspaces of the lung are being unravelled largely as a result of the explosion of studies in animals. At the forefront of this has been the use of genetically manipulated mice, and the evolution and understanding of different models of emphysema. This review will summarise the current models of emphysema.
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Cite this article as:
Mahadeva Ravi and Shapiro D. Steven, Animal Models of Pulmonary Emphysema, Current Drug Targets - Inflammation & Allergy 2005; 4 (6) . https://dx.doi.org/10.2174/156801005774912860
DOI https://dx.doi.org/10.2174/156801005774912860 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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