Chest
Clinical InvestigationsPulmonary Hypertension, Hypoxemia, and Hypercapnia in Obstructive Sleep Apnea Patients
Section snippets
Patients
As part of the evaluation of the severity of OSA before adequate treatment, 114 consecutive OSA patients (108 men, six women) referred to our Sleep Laboratory for symptoms evocative of OSA, including daytime somnolence (74 patients), snoring (25 patients), respiratory failure without a clear origin (eight patients), and observation of respiratory arrests during sleep (seven patients), underwent standard polysomnography (n = 114), pulmonary function tests (n = 112), right heart catheterization
RESULTS
The patients' anthropometric and main respiratory function, right heart catheterization, and polysomnographic data are given in Table 1. As a group, their values were within the normal range for all parameters studied except BMI. The individual values covered a wide range, from normal to pathologic (Fig 1). None of the observed distributions was significantly different from normal except that of mean minimal SaO2.
DISCUSSION
In this group of 114 unselected OSA patients, 19 of 100 (19 percent) had daytime pulmonary hypertension, 37 of 112 (33 percent) had daytime hypoxemia, and 13 of 112 (12 percent) had daytime hypercapnia. Pulmonary hypertension may have been slightly underestimated because the 14 patients who did not undergo right heart catheterization were more overweight and had lower TLC, which may be contributory factors to pulmonary hypertension. However, using the model to predict the missing PAP values
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