Chest
Pulmonary Alveolar Proteinosis: Occurrence with Metastatic Melanoma to Lung
Section snippets
CASE REPORT
A 24-year-old man was referred to our institution for management of malignant melanoma. He had developed a nodular lesion over the right scapula several months after sustaining local trauma. When initially seen by the referring physician, the patient reported significant recent weight loss attributed to loss of appetite and poor eating habits. He had a 20 pack-year smoking history with stable chronic cough and a seizure disorder, which was controlled by primidone and carbamazepine. He had no
DISCUSSION
Pulmonary alveolar proteinosis (PAP) is characterized by excess accumulation of a surfactant-like material in the alveoli, resulting in part from defective alveolar clearance by macrophages. PAP has been described as an isolated process, in conjunction with a variety of inflammatory conditions such as infection and silicosis, and with hematologic malignancies of the immune or hematopoetic systems, including leukemia, lymphoma, and blood dyscrasias.1-3
In many of these conditions, defective or
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