Chest
Clinical InvestigationsCough Capacity in Patients with Muscular Dystrophy
Section snippets
MATERIAL AND METHODS
Twenty-two patients with MD were included in the study. Patient characteristics are summarized in Table 1. The following parameters were evaluated.
RESULTS
The 14 subjects of the control group, six females and eight males, age range 9 to 35 years (median age, 14 years) were all classified as having a strong cough and all generated transients of peak flow during the cough flow-volume maneuver. The range of their spirometric and maximal expiratory pressure measurements were as follows: FVC, 82 to 108 percent predicted; PEFR, 85 to 120 percent predicted; and MEP, 78 to 130 percent predicted (100 to 290 cm H2O). A representative example of peak flow
DISCUSSION
In this study we have shown that 12 of 22 patients with muscular dystrophy were unable to produce transients of peak flow during cough flow-volume maneuvers. In contrast, all of the subjects in the control group exhibited transients. The production of these peak flow transients plays an important role in the efficacy of the cough mechanism.
Cough flow-volume tracings from those patients who could generate transients of peak flow and from the control subjects were similar to those previously
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