Chest
Predicting Maximal Exercise Ventilation in Patients with Chronic Obstructive Pulmonary Disease
Section snippets
Subjects
Fifty-three patients, 36 men and 17 women, with chronic obstructive pulmonary disease were studied. All patients met the following criteria: 1) radiographic evidence of COPD; 2) ratio of FEV1 to FVC (FEV1/FVC) of less than 50 percent; 3) total lung capacity of greater than 80 percent of predicted; 4) change in FEV1 of less than 20 percent following bronchodilator administration; 5) emax to MVV ratio greater than 80 percent; and 6) no underlying cardiac symptomatology which would limit
RESULTS
The study group (Table 2) consisted of 36 men and 17 women with a racial composition of 49 whites, three blacks and one Hispanic. Ages ranged from 38 to 75 years (mean 62 years). FEV1 ranged from 0.56 to 1.64 L. The mean values for TLC, VC and IC were 7.25, 2.78 and 1.83 L respectively.
Exercise capacity, presented in Table 3, varied greatly among patients tested. Peak workload ranged from 10 to 100 watts, peak oxygen uptake ranged from 347 to 2,470 ml/min, and maximal ventilation ranged from 16
DISCUSSION
In patients with COPD, the ventilatory pump undoubtedly contributes to exercise limitation.22 Thus, by understanding the ventilatory limits imposed by the disease process, a more accurate assessment of exercise limitation can be made. In addition, this knowledge will help the clinician judge the true ventilatory reserve prior to exercise testing, thus allowing for selection of an appropriate exercise protocol.
Currently, two distinct types of regression equations are employed for predicting
ACKNOWLEDGMENT
We wish to thank Gerri Dingler for typing this manuscript; Willie Blevins, David Campbell, Marla Harter, Pat Smith, Barbara Pruitt, Judy Berry, Dana Griner and Jon Divine for their technical assistance.
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Supported in part by a grant from Ray and Ipha Morrow.
Manuscript received May 12; revision accepted December 16.