Chest
Original ResearchIncreased COPD Among HIV-Positive Compared to HIV-Negative Veterans
Section snippets
Materials and Methods
VACS 5 is an observational study of 1,031 HIV-positive and 740 HIV-negative subjects matched for age, race, and site who were enrolled from 2001 to 2002 from the outpatient infectious disease and general medicine clinics at five US Veterans Affairs (VA) medical centers. The institutional review boards approved the study at all locations, and participants provided written informed consent. All consecutive HIV-positive patients were eligible to participate, and the 1,031 HIV-positive subjects
Results
We excluded female subjects (n = 42) and those subjects without a known smoking status (n = 2). Thus, 1,727 of 1,771 subjects (98%) who were enrolled in VACS 5 were included in the analytic sample.
Discussion
In this study, we found that HIV infection was an independent risk factor for COPD in the present HAART era. Although the prevalence of COPD was not significantly different in HIV-positive and HIV-negative subjects by univariate analysis, the HIV-positive subjects were significantly younger and had smoked fewer pack-years of cigarettes than the HIV-negative subjects. Both of these factors would be expected to decrease the likelihood of COPD in the HIV-positive group. However, after we adjusted
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
This research was supported by National Institutes of Health/National Center for Research Resources grant K12 RR0117594-01 (to K.C.), National Institute on Alcohol Abuse and Alcoholism grant 3U01 AA 13566, National Institute on Aging (NIA) grant K23 AG00826, a Robert Wood Johnson Generalist Faculty Scholar Award, and an Interagency Agreement among NIA, National Institute of Mental Health, and Veterans Health Affairs (to A.C.J.).
Data for this study were collected from subjects enrolled in VACS 5 at five Veterans Affairs Medical Centers in the United States (Atlanta, the Bronx, Houston, Los Angeles, and Manhattan). Data were analyzed at the coordinating center at the West Haven Veterans Affairs Medical Center, West Haven, CT.