Chest
Original Research: Interventional PulmonologyComparison of Endobronchial Ultrasound, Positron Emission Tomography, and CT for Lymph Node Staging of Lung Cancer
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Patients
From December 2003 to March 2005, patients with suspected or pathologically established lung cancer referred to the Department of Thoracic Surgery, Chiba University Hospital were enrolled in this study. All patients were evaluated by history; physical examination; CBC count; renal, liver, and pulmonary function tests; chest radiography; CT scan of the chest and upper abdomen; brain MRI; bone scan; and FDG-PET. All tests were presented in a multidisciplinary session, and the staging of the
Patients
From December 2003 to March 2005, a total of 280 patients with suspected or pathologically established lung cancer were evaluated by the multidisciplinary group. Of these 280 patients, 178 patients were not further evaluated for presence of distant metastasis, tumor resectability, or medical operability. The remaining 102 patients with proven (n = 96) or suspected (n = 6) lung cancer fulfilled the criteria and underwent CT, PET, and EBUS-TBNA for mediastinal staging prior to surgery. The
DISCUSSION
Our report is the first study to compare CT, PET, and EBUS-TBNA for mediastinal staging of potentially operable lung cancer patients. EBUS-TBNA was performed in 102 potentially resectable patients with lung cancer or suspected lung cancer. The sensitivity, specificity, and accuracy of EBUS-TBNA for the prediction of mediastinal lymph node staging were 92.3%, 100%, and 98.0%, respectively. EBUS-TBNA was highly sensitive and specific compared to CT and PET. As a single procedure for mediastinal
REFERENCES (35)
- et al.
Percutaneous biopsy in lung cancer
Eur J Radiol
(2003) Revisions in the international system for staging lung cancer
Chest
(1997)- et al.
Treatment of stage IIIA non-small cell lung cancer
Chest
(2003) - et al.
Transbronchial needle aspiration for histology specimens
Chest
(1989) - et al.
CT fluoroscopy guidance for transbronchial needle aspiration: an experience in 35 patients
Chest
(2001) - et al.
Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial
Chest
(2004) - et al.
Towards a minimally invasive staging strategy in NSCLC: analysis of PET positive mediastinal lesions by EUS-FNA
Lung Cancer
(2004) - et al.
Real-time endobronchial ultrasound guided transbronchial needle aspiration of mediastinal and hilar lymph nodes
Chest
(2004) - et al.
Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer
Lung Cancer
(2005) - et al.
Regional lymph node classification for lung cancer staging
Chest
(1997)
Mediastinal lymph node staging of non-small cell lung cancer: a perspective comparison of computed tomography and positron emission tomography
Thorac Cardiovasc Surg
Mediastinal lymph node staging with FDG-PET scan in patients with potentially operable non-small cell lung cancer: a prospective analysis of 50 cases; Leuven Lung Cancer Group
Chest
Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging
Chest
Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
Lancet
Cancer statistics, 2003
CA Cancer J Clin
Lung cancer screening with sputum cytologic examination, chest radiograph, and computed tomography: an update for the U.S. Preventive Service Task Force
Ann Intern Med
Sputum examination for early detection of lung cancer
J Clin Pathol
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All authors have no conflicts of interest to disclose.
Supported by a grant from The Japanese Foundation for Research and Promotion of Endoscopy to Dr. Yasufuku.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).