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Clinical Investigations: AsthmaA Comparison of Bone Mineral Density in Elderly Female Patients with COPD and Bronchial Asthma
Section snippets
Subjects
Forty-four elderly female Japanese patients with COPD (n = 20) and bronchial asthma (n = 24) regularly followed up at the outpatient clinic of Tokyo Metropolitan Geriatric Medical Center were recruited for this study. The criteria for diagnoses of COPD and bronchial asthma were based on the standards of the American Thoracic Society.7 None of the patients had a history of chronic systemic corticosteroid use, defined as any oral steroids received continuously for > 1 week during the previous 10
Results
Patient characteristics, anthropometric variables, and details of inhaled corticosteroid use are shown in Table 1. All patients with COPD were ex-smokers; however, none of the patients with bronchial asthma had a smoking habit. Compared to patients with bronchial asthma, the patients with COPD were relatively lean and the body mass index (BMI) was significantly smaller (p < 0.04). FEV1 expressed as percentage of predicted value was significantly lower in patients with COPD (p < 0.01), but ADL
Discussion
In this study, we compared the degree of BMD and bone turnover markers between elderly women with COPD and elderly women with bronchial asthma who had not received chronic systemic corticosteroids, and determined the factors that influence bone metabolism in these patients. This study has clearly shown that even in elderly women with COPD who have not received chronic systemic corticosteroids, total body and lumbar BMD was much lower than that in asthmatic patients. The prevalence of
ACKNOWLEDGMENT
The authors thank Dr. Takayuki Hosoi of the Department of Endocrinology, Tokyo Metropolitan Geriatric Medical Center for his helpful discussion.
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This study was supported by a grant from the Pollution-Related Health Damage Compensation and Prevention Association of Japan.