Chest
Clinical InvestigationsSarcoidosisCharacteristics and Outcomes of Patients With Sarcoidosis Listed for Lung Transplantation
Section snippets
Study Population
Between January 1991 and May 2000, 56 patients with sarcoidosis were evaluated in the University of Pennsylvania Lung Transplant Program. All patients underwent a standard battery of tests that included pulmonary function testing (ie, spirometry, lung volume measurements by body plethysmography, and single-breath diffusing capacity) (MedGraphics System 1085; Medical Graphics Inc; St. Paul, MN), measurement of room air arterial blood gas, 6-min walk testing, chest radiography, echocardiography,
Characteristics of Listed Patients
The demographic, clinical, and physiologic characteristics of the 43 patients who were listed are summarized in Table 1. The mean (± SD) age of patients was 45 ± 8 years. There were 34 black and 9 white patients in the group; 15 patients were men and 28 were women. The diagnosis of sarcoidosis was established 13 ± 8 years prior to listing, and respiratory symptoms had been present for 10 ± 7 years. Forty-seven percent of patients had extrapulmonary involvement, 77% were receiving prednisone,
Discussion
In this study, we have examined the clinical course of 43 patients with advanced sarcoidosis listed for lung transplantation in an attempt to identify prognostic indexes. Our study demonstrates that the mortality rate in this group is very high, with approximately half of listed patients dying prior to transplantation and a median survival time for the group of < 2 years. Notably, we have shown that hypoxemia, pulmonary hypertension, diminished cardiac index, and elevated RAP are associated
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This research was supported by the Craig and Elaine Dobbin Pulmonary Research Fund.
This article was presented in part at the American Thoracic Society Meeting, Toronto, Canada, in May 2000.