Chest
Volume 117, Issue 5, Supplement 1, May 2000, Pages 250S-251S
Lung Neutrophil Burden Correlates With Increased Pro-Inflammatory Cytokines and Decreased Lung Function in Individuals With α1-Antitrypsin Deficiency
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Alpha-1 antitrypsin deficiency–associated panniculitis
2021, Journal of the American Academy of DermatologyCitation Excerpt :Moreover, Z-AAT polymers are neutrophil chemoattractant30-32 and have been shown at skin biopsy alongside immunoglobulin M and complement C3.33 Studies have shown AAT polymers in the lungs of ZZ individuals34 and that AATD results in an increased influx of neutrophils into the lungs.30,35 These mechanisms may mirror the pathophysiology of AATD-associated panniculitis.
Alpha-1 Antitrypsin Therapy Modifies Neutrophil Adhesion in Patients with Obstructive Lung Disease
2022, American Journal of Respiratory Cell and Molecular Biology
Funding by the Division of Intramural Research, NHLBI, NIH, and the University of Florida
Copyright © 2000 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.