Chest
Clinical InvestigationsBRONCHOSCOPYSerum Lidocaine Concentrations in Asthmatics Undergoing Research Bronchoscopy
Section snippets
Subjects
Fifty-one asthmatic volunteers ranging in age from 19 to 62 years (33.5 ± 9.6 years; mean ± SD) were recruited from the general Denver community. All subjects met diagnostic criteria for asthma.11 Exclusion criteria included any history of significant nonasthmatic pulmonary disease, significant nonpulmonary disease (including cardiac, liver, or kidney disease), pregnancy, and any history of tobacco use during the past 1 year or > 5 pack-years of total use. All subjects gave informed consent to
Clinical Evidence of Lidocaine Toxicity
Among the 51 subjects who underwent bronchoscopy, there were no observed signs or symptoms of CNS, cardiac, or respiratory lidocaine toxicity, nor were there any significant adverse events reported during the 24 h after the procedure.
Amount of Lidocaine Administered
The mean total amount of lidocaine administered, as calculated by adding the amount of 4% and 1% lidocaine given to the subject for the entire procedure, was 600 ± 122 mg. The total amount of lidocaine administered ranged between 320 and 880 mg. Expressed per
Discussion
In this group of young, otherwise healthy volunteers with mild to moderate asthma, SLC measured during bronchoscopy, 30 min after upper airway anesthesia, and 30 min after bronchoscopy did not fall into the potentially toxic range (≥ 5 mg/L) for any of the subjects. This was true even though the average total amount of lidocaine administered, 600 ± 122 mg, exceeded the 400-mg total dose limit previously recommended for investigative bronchoscopy.1 None of the subjects displayed signs or
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Cited by (0)
Supported by NHLBI grants HL36577 (Drs. Kraft and Martin) and HL03343 (Dr. Kraft), and the American Lung Association Asthma Research Center Award (Drs. Kraft and Martin).