Chest
Clinical Investigations: AsthmaLongitudinal Determinants of Bronchial Responsiveness to Inhaled Histamine
Section snippets
Subjects
A sample of 983 children and adolescents living in the area surrounding Rigshospitalet in the city of Copenhagen was drawn at random from the civil registration list in 1986; all subjects were born in the first week of each month with a mean age of 12 years (range, 7 to 17 years). In 1986 (first survey) and 1992 (second survey), all subjects (n=983) were invited by letter to participate in a study concerning asthma, allergy, and BHR.
Of the 983 subjects, 527 (54%) participated in the first
RESULTS
Complete data were available for 408 subjects, 199 male and 209 female; characteristics of the examined subjects are displayed in Table 1. The proportion of subjects with current asthma increased from 5% at the first survey to 15% at the second survey (Table 2); and likewise did the point prevalence of a positive SPT increase from 26 to 44% (Table 2).
The prevalence of a positive histamine challenge test declined from 25% (n= 102) at the first survey to 6% (n=24) at the second survey, of whom 81
DISCUSSION
The present study showed an overall decline in BR to inhaled histamine from childhood to early adulthood, possibly reflecting the growth-related increase in airway caliber, and furthermore, the level of FEV1 %pred, as an index of airway caliber, and atopy, especially to HDMs, are important determinants for changes over time in degree of histamine responsiveness in both asthmatic and nonasthmatic subjects.
The present population study not only confirmed that prechallenge airway caliber has a
REFERENCES (28)
- et al.
Risk factors for development of asthma in children and adolescents: findings from a longitudinal population study
Respir Med
(1996) - et al.
Specificity and sensitivity of methacholine inhalation challenge in normal and asthmatic children
J Allergy Clin Immunol
(1984) Factors associated with increased bronchial responsiveness in adolescents and young adults: the importance of adjustment for prechallenge FEV1
J Allergy Clin Immunol
(1996)- et al.
Bronchial reactivity to inhaled histamine: a method and clinical survey
Clin Allergy
(1977) - et al.
Factors associated with bronchial hyperresponsiveness in Australian adults and children
Eur Respir J
(1992) - et al.
The interrelationship among bronchial hyperresponsiveness, the diagnosis of asthma, and asthma symptoms
Am Rev Respir Dis
(1990) - et al.
Sensitivity and specificity of the histamine challenge test for the diagnosis of asthma in an unselected sample of children and adolescents
Eur Respir J
(1991) Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma
Clin Exp Allergy
(1995)- et al.
The relationship between airway responsiveness to histamine and pulmonary function level in a random population sample
Am Rev Respir Dis
(1988) - et al.
Published models and local data can bridge the gap between reference values for children and adults
Eur Respir J
(1997)
Airway hyperresponsiveness: relevance of random population data to clinical usefulness
Am Rev Respir Dis
Longitudinal changes in atopy during a 4-year period: relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren
J Allergy Clin Immunol
The presence of airway reactivity before the development of asthma
Am Rev Respir Dis
Comparison of stayers, drop-outs and newcomers in a longitudinal population study of asthma and bronchial hyperresponsiveness: introduction of bias?
J Asthma
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This study was supported by the National Union for the Fight Against Lung Diseases.