Chest
Clinical InvestigationsMixed (Neutrophil-Rich) Interstitial Pneumonitis in Biopsy Specimens of Lung Allografts: A Clinicopathologic Evaluation
Section snippets
Materials and Methods
We retrospectively reviewed all lung (transbronchial) biopsy reports from single, double, and heart/lung transplant recipients from the surgical pathology files of the St. Louis University Hospital from July 1992 to August 1996. Within this time frame were 278 biopsy specimens from a total of 29 lung allograft recipients (range, 1 to 17 biopsy specimens per patient). The transbronchial biopsy specimens each were represented by three levels of hematoxylin-eosin-stained slides as well as
Results
Applying the previously described criteria for MIP led to the selection of 13 biopsy specimens (4.7% of total) from seven patients (23% of total). The clinical characteristics of the seven patients with MIP are listed in Table 1. Their average age at transplantation of 40 years (SD, 10; range, 23 to 57 years) was similar to that of the other 22 lung allograft recipients within the selected time period (average, 43 years; SD, 13; range, 18 to 58 years). Their native diseases were emphysema
Discussion
MIP is a histologic finding encountered in 13 transbronchial biopsy specimens from 7 lung allograft recipients over an approximately 4-year period at Saint Louis University Hospital. Our retrospective study of posttransplant lung biopsies in this time period showed a statistically significant (p<0.01) difference in posttransplantation survival in patients who showed MIP (2/7 patients, 28%) compared to patients who did not show this finding (20/22 patients, 91%).
The fact that the incidence of
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Cited by (8)
Nonadherence to the medical regimen after lung transplantation: A systematic review
2017, Heart and Lung: Journal of Acute and Critical CareCitation Excerpt :Among the other elements of the post-transplant medical regimen, tobacco use was the mostly studied area in the literature. Seven articles14,35–40 examined nonadherence to tobacco use. While two articles14,37 found low nonadherence rates (less than 2%), other articles35,36,38–40 reported higher nonadherence rates, ranging from 12%39 to 45%.36
Interstitial pneumonitis and the risk of chronic allograft rejection in lung transplant recipients
2013, ChestCitation Excerpt :Previously published studies examined the cross-sectional importance of pneumonitis in transplant recipients. McDonald et al16 noted that mixed IP accompanied 4.7% of allograft biopsy specimens across a 50-month sampling period. The authors of that study demonstrated that IP did not correlate with evidence of acute allograft rejection.
Pathology of the lungs: Expert consult: Online and print
2011, Pathology of the Lungs: Expert Consult: Online and PrintPathology of the Lungs
2011, Pathology of the Lungs