Chest
Volume 112, Issue 6, December 1997, Pages 1657-1664
ReviewsPenicillin Dosing for Pneumococcal Pneumonia
Section snippets
Historical Overview
Doses of penicillin used in the early 1940s were minuscule by today's standards. The classic studies on the pharmacokinetics of penicillin G given IV were done with 20,000 to 40,000 Florey units.38 By 1945, a recommended regimen for severe pneumococcal pneumonia consisted of 25,000 U IV every 3 h (q3h) for two doses, then 10,000 U IM q3h for two doses.39 By 1946, it was noted that “sometimes the drip method is preferred to the intramuscular route by the scientific clinician but seldom is it
Dosing Considerations
Four issues pertaining to IV penicillin G therapy will be considered: intermittent vs continuous infusion; high dose vs low dose; the relationship of dose to resistance; and cost.
References (99)
- et al.
Pneumococcal bacteremia in three community teaching hospitals from 1980 to 1989
Chest
(1993) - et al.
Effect of schedule of administration on the therapeutic efficacy of penicillin: the effect of the aggregate time penicillin remains at effectively bactericidal levels
Am J Med
(1950) - et al.
Defective platelet function following the administration of penicillin compounds
Blood
(1976) - et al.
The penicillins
Mayo Clin Proc
(1991) - et al.
Effect of storage of penicillin-G solutions on sensitisation to penicillin-G after intravenous administration
Lancet
(1982) - et al.
Penicillin-resistant pneumococci—an emerging threat to successful therapy
J Hosp Infect
(1995) The antibiotic treatment of community-acquired, atypical, and nosocomial pneumonias
Med Clin North Am
(1995)1996 pocket book of infectious disease therapy
(1996)Acute infectious diseases of the lungs: acute bronchitis and pneumonia
- et al.
Pneumonia caused by pyogenic bacteria
Infectious diseases, tropical medicine and STDs
Principles and practice of infectious diseases: antimicrobial therapy 1995/1996
(1995)
Med Lett
(1996)
Pulmonary infections
Guide to antimicrobial therapy
(1996)
Community-acquired pneumonia
Louis
(1993)
Pneumococcal infections
Scientific American CD ROM 5
(1996)
Pneumococcal pneumonia
Streptococcus pneumoniae
Pneumonia
Pyogenic bacterial pneumonia
Textbook of respiratory medicine. 2nd ed
(1994)
The Merck manual of diagnosis and therapy
(1992)
Treatment of infectious diseases
Pneumonia
Pneumococcal infection
Pneumococcus
Respiratory tract infections
Infectious disease handbook
(1997)
Cleveland
(1996)
Streptococcal infections
Infectious diseases: bacterial and chlamydial
Pneumonia
Antibiotic treatment of community-acquired pneumonia in clinical practice: a European perspective
J Antimicrob Chemother
(1995)
Pneumococcal bacteraemia in south Auckland: a 5 year review with emphasis on prescribing practices
NZ Med J
(1992)
Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy
Am Rev Respir Dis
(1993)
Guidelines for the initial management of community-acquired pneumonia: savory recipe or cookbook for disaster
Am J Respir Crit Care Med
(1995)
Community-acquired pneumonia
N Engl J Med
(1995)
Cephalosporin treatment failure in penicillin- and cephalosporin-resistant Streptococcus pneumoniae meningitis
Pediatr Infect Dis J
(1992)
Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci
Lancet
(1996)
Update in infectious diseases
Ann Intern Med
(1997)
Defining the public health impact of drug-resistant Streptococcus pneumoniae: report of a working group
MMWR
(1996)
Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain
N Engl J Med
(1995)
Confronting drug-resistant pneumococci [editorial]
Ann Intern Med
(1994)
Minimizing the impact of drug-resistant Streptococcus pneumoniae (DRSP): a strategy from the DRSP working group
JAMA
(1996)
The absorption, excretion, and distribution of penicillin
J Clin Invest
(1943)
The treatment of lobar pneumonia with penicillin
J Clin Invest
(1945)
Chest infections
Pneumococcal infections
High-dose penicillin therapy and pneumococcal pneumonia
JAMA
(1974)
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Copyright © 1997 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.