Chest
Original ResearchLung CancerCharacteristics of Subsolid Pulmonary Nodules Showing Growth During Follow-up With CT Scanning
Section snippets
CT Scan Selection and Review
From > 60,000 CT scan examinations carried out at the Tochigi Cancer Center between January 2000 and June 2008, we extracted 1,065 cases for which descriptive terms referring to GGO were used in the reports. We reviewed all images from the cases and selected target cases according to the following criteria: subsolid nodules ≤ 2.0 cm in diameter, performance of at least one high-resolution CT (HRCT) scan and a follow-up CT scan, and a proportion of GGO > 20%. We used these criteria because we
Results
Regarding type of subsolid nodule, nonsolid nodule cases numbered 98 and part-solid nodule cases numbered 76. Patients' characteristics according to the type of subsolid nodule are shown in Table 1. Pathologic examination revealed that three patients were diagnosed with atypical adenomatous hyperplasia (AAH), 36 had AIS, 11 had MIA, and six had invasive adenocarcinoma according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society
Discussion
In this study, some patients underwent resection at different points of growth, and because of their older age and comorbidity, others continued to be followed up in spite of growth. In this situation, we selected the Kaplan-Meier method to calculate the percentage of subsolid nodules showing growth because this method can be implemented to deal with censored cases. In the analysis with the Kaplan-Meier method, we set ≥ 2 mm growth as an event for the following reasons: a 2 mm size change is a
Acknowledgments
Author contributions: Dr Matsuguma had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Matsuguma: contributed to study design, data acquisition, and manuscript preparation.
Dr Mori: contributed to manuscript preparation and read and approved the final manuscript.
Dr Nakahara: contributed to manuscript preparation and read and approved the final manuscript.
Dr Suzuki: contributed to manuscript preparation and
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Funding/Support: This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan, and by the second-term comprehensive 10-year strategy for cancer control.
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