Chest
Clinical Investigations: COPDNutritional State and Exercise Tolerance in Patients With COPD
Section snippets
Materials and Methods
Twenty-eight male ambulatory patients with COPD with mild to severe stable airways obstruction and mild hypoxemia were studied. Admission criteria included the following: clinical diagnosis of COPD,28 exertional dyspnea, FEV1 <60% of predicted, and room air PaO2 >55 mm Hg. The pertinent clinical and functional characteristics of the subjects are summarized in Table 1; in 16 of the 28 patients, a physiologic pattern of predominant emphysema was recognizable, ie, flattening of diaphragmatic
Results
Subjects were divided into three groups, according to %IBW: GP1 (n=8, %IBW <90); GP2 (n=13, %IBW ≥90<110); and GP3 (n=7, %IBW ≥110). The distribution of %IBW and resting respiratory indexes of the patient population are described in Table 2. Mean %IBW and mean BMI were statistically different among the three groups. The TSF was markedly reduced in GP1 (8.1±0.5 mm) vs GP2 (18.1 ±0.5 mm) as well as vs GP3 (16.2±0.3 mm), p<0.05 for both, documenting that body fat mass was reduced. Among
Discussion
Reduced exercise tolerance is generally accepted as an inavoidable complication of advanced COPD; the presence of different degrees of physical limitation in patients with comparable lung function impairment, however, suggests a multifactorial origin for this phenomenon. Although airways obstruction has classically been considered the most important of these pathogenetic factors, studies aimed at comparing lung function impairment and exercise tolerance in COPD failed to establish a clear
References (42)
Exercise in chronic obstructive pulmonary disease
Clin Chest Med
(1986)- et al.
Determinants of maximum exercise capacity in patients with chronic airflow obstruction
Chest
(1989) - et al.
Prediction of maximum exercise tolerance in patients with COPD
Chest
(1991) - et al.
Oxygen transport and oxygen consumption during supplemental oxygen administration in patients with chronic obstructive pulmonary disease
Am J Med
(1989) - et al.
Anthropometric and pulmonary function test profiles of outpatients with stable chronic obstructive pulmonary disease
Am J Med
(1993) - et al.
Factors affecting prognosis in emphysema
Dis Chest
(1964) - et al.
Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease: use of the V-slope method for anaerobic threshold determination
Chest
(1988) - et al.
Exercise impairment in chronic obstructive pulmonary disease
Clin Chest Med
(1984) - et al.
Hypophosphatemia in course of chronic obstructive pulmonary disease: prevalence, mechanisms, and relationships with skeletal muscle phosphorus content
Chest
(1990) - et al.
Oxygen may lower the O2 cost of ventilation in chronic obstructive lung disease
Chest
(1992)
Nutritional status and lung function in patients with emphysema and chronic bronchitis
Chest
Interpretation of clinical exercise testing in respiratory disease
Clin Chest Med
Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation
Am Rev Respir Dis
Fiber size and energy metabolites in five separate muscles from patients with chronic obstructive lung disease
Respiration
Ventilatory and gas exchange kinetics during exercise in chronic airways obstruction
J Appl Physiol
Effect of O2 on V˙O2 kinetics and other cardiorespiratory parameters during exercise in COPD
Clin Res
A magnetic resonance spettroscopy study of ATP production in COPD patients with varying levels of hypoxemia
Clin Res
Impairment of muscular metabolism in chronic respiratory failure: a human P31 MRS study
NMR Biomed
Muscular metabolism during oxygen supplementation in patients with chronic hypoxemia
Am Rev Respir Dis
31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure
Eur Respir J
Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease
Am Rev Respir Dis
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