Chest
Clinical Investigations: MiscellaneousSingle Lung Transplantation in Patients With Systemic Disease
Section snippets
METHODS
Single lung transplantation was performed according to a previously established surgical protocol.8 Prior to SLT, following SLT on a weekly and then monthly basis, and during episodes of suspected rejection, each recipient underwent pulmonary function testing (PFT) as part of the surveillance program of the UTHSCSA Organ Transplant Service. Spirometric and body plethysmographic static lung volume measurements, single breath carbon monoxide diffusing capacity, and arterial blood gas measurements
Subjects
Patient 1, a 59-year-old man with a 20-year history of sarcoidosis and secondary pulmonary hypertension (mean pulmonary artery pressure [PAM] = 35 mm Hg), underwent SLT in June 1989. He was in the intensive care unit receiving dobutamine for severe right heart failure at the time. Patient 2, a 60-year-old woman with a 25-year history of sarcoidosis with secondary pulmonary hypertension (PAM = 40 mm Hg) underwent SLT in September 1990 following deterioration of pulmonary function. Patient 3, a
DISCUSSION
Despite concerns of performing SLT in patients with systemic diseases, our center and others7 have successfully transplanted lungs in nine patients with either sarcoidosis, scleroderma, or prior malignancy. In the past, systemic disease has been considered a contraindication to SLT due to the potential for increased postoperative complications. Specifically, patients with a disease exhibiting multiorgan involvement of the liver or kidneys could have problems tolerating postoperative
REFERENCES (13)
- et al.
Preoperative assessment for lung transplantation
Clin Chest Med
(1990) - et al.
Washington University Lung Transplantation Group. Analysis of referrals for lung transplantation
Chest
(1991) - et al.
Selection and evaluation of recipients for heart-lung and lung transplantation
Chest
(1990) - et al.
Single lung transplantation—alternative indications and technique
J Thorac Cardiovasc Surg
(1991) - et al.
Single lung transplantation for primary pulmonary hypertension
Chest
(1990) - et al.
Ventilation-perfusion inequalities during graft rejection in patients undergoing single lung transplantation for primary pulmonary hypertension
Chest
(1992)
Cited by (0)
Supported in part by the General Medical Research Service of the Department of Veterans Affairs and the National Heart, Lung, and Blood Institute Grant HL-32824.