Chest
Serum Neopterin After Lung Transplantation
Section snippets
Patient Population
Forty-four patients (26 male, 18 female), aged 9 to 61 years, were studied from November 1989 to April 1991. They underwent single lung (6 patients), double lung (12 patients), or heart-lung transplantation (26 patients) between January 1987 and March 1991. All these patients were studied after the first 3 weeks after transplantation. Twenty-two of them underwent transplantation during the prospective study and were therefore studied during the early postoperative period (first 3 weeks after
Early Dynamic Changes of Serum N/C Ratio After Lung Transplantation
The variations of serum N/C ratio were followed for the first 21 days after transplantation in 22 long/heart-lung recipients (311 samples). A preoperative blood sample was available from 19 patients. The mean preoperative serum N/C ratios in these patients (87 ± 11 µmol/mol) were not different from the values observed in a normal blood donor population. The only patient with an elevated preoperative serum N/C ratio (patient 8, N/C = 240 µmol/mol) was febrile prior to transplantation (38°C) and
DISCUSSION
The aim of this study was to determine the dynamics of the serum N/C ratio after lung transplantation, and the variations of this ratio during major and frequent posttransplantation complications (allograft rejection, CMV pneumonia, and obliterative bronchiolitis). Overall, the serum N/C ratio was a sensitive but nonspecific marker of immune activation in the first 21 days following transplantation. We also showed that an increased N/C ratio later after lung transplantation was related to
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Support by grants from the Association Française de Lutte contre la Mucoviscidose.
Manuscript received February 4; revision accepted June 26.