Chest
Volume 131, Issue 2, February 2007, Pages 335-336
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Conflicting Definitions of Airways Obstruction: Drawing the Line Between Normal and Abnormal

https://doi.org/10.1378/chest.06-2736Get rights and content

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  • Longer duration of asthma is significantly associated with increased RV/TLC ratio

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    Presence of obstruction has been diagnosed by the disproportionate decrease of FEV1 (forced expiratory volume in 1 s) over FVC (forced vital capacity) leading to a low FEV1/FVC ratio. However, there has been considerable debate regarding the use of fixed value versus the lower limit of FEV1/FVC ratio to diagnose obstruction in asthma [3,4]. Although a trend for decline in FEV1% predicted value with time has been observed in children with persistent asthma symptoms [5], previous studies have shown that spirometry indices do not correlate with symptoms or severity of asthma [6,7].

  • Pulmonary function impairment in patients with chronic heart failure: Lower limit of normal versus conventional cutoff values

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    This is explained by the physiological decrease of the FEV1/FVC ratio with age. The FEV1 declines more rapidly with age than the FVC in normal subjects.23 As a result, the fixed ratio of 0.7, that is traditionally used because of its simplicity, may lead to overdiagnosis in the elderly and underdiagnosis in younger patients.

  • COPD in chronic heart failure: Less common than previously thought?

    2013, Heart and Lung: Journal of Acute and Critical Care
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    Although spirometry is considered to be the gold standard for the diagnosis of COPD,2 data on the prevalence of COPD based on spirometry in patients with HF are scarce.3–7 Moreover, even when spirometry is used, in general there is still no consensus on how to define COPD.8–11 The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend the use of a fixed ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) < 0.70 for the sake of simplicity.2

  • Open letter to the members of the GOLD committee

    2010, Revue des Maladies Respiratoires
  • Target Sites: Respiratory

    2009, Information Resources in Toxicology, Fourth Edition
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