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Planta Med 2000; 66(5): 469-471
DOI: 10.1055/s-2000-8592
Letter
Georg Thieme Verlag Stuttgart · New York

Inhibitors of Nitric Oxide Synthesis and TNF-α Expression from Magnolia obovata in Activated Macrophages

Haeng Ja Son1 , Hwa Jin Lee1 , Hye Sook Yun-Choi2 , Jae-Ha Ryu1,*
  • 1 College of Pharmacy, Sookmyung Women's University, Seoul, Korea
  • 2 Natural Products Research Institute, Seoul National University, Seoul, Korea
Further Information

Publication History

Publication Date:
31 December 2000 (online)

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Abstract

Nitric oxide (NO) and tumor necrosis factor-α (TNF-α) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. An activity-guided fractionation of an MeOH extract of stem bark of Magnolia obovata afforded two inhibitors of NO production in lipopolysaccharides (LPS)-activated macrophages by the suppression of i-NOS expression. Their structures were elucidated by spectroscopic methods to be magnolol and honokiol with IC50 values of 16.8 and 6.4 μM, respectively. They also inhibited the production of TNF-α in LPS-activated macrophages. Thus, these compounds may be possible candidates for the development of new drugs to treat endotoxemia accompanied by the overproduction of NO and TNF-α.

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Prof. Jae-Ha Ryu

College of Pharmacy Sookmyung Women's University

Chungpa-Dong 2-Ka

Yongsa-Ku

Seoul 140-742

Korea

Email: ryuha@sdic.sookmyung.ac.kr

Phone: +82-2-714-0745

Fax: +82-2-710-9568

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