SERIES: NEW BIOLOGY OF THE AIRWAYSThe role of the collectin system in pulmonary defence
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Cited by (21)
Question 6: Is there a role for Mannose-Binding Lectin measurement in Cystic Fibrosis management?
2016, Paediatric Respiratory ReviewsCitation Excerpt :Nevertheless, there have been several studies published that do not show an increased susceptibility to infections in MBL deficiency [13,14]. MBL has been shown to bind to organisms clinically relevant to cystic fibrosis (CF) patients including Staphylococcus aureus, Aspergillus fumigatus, Haemophilus influenzae and Burkholderia cepacia, and to a lesser extent Pseudomonas aeruginosa [10,15]. Differential binding capacities against these specific pathogens has been reported [16], however, the clinical significance of these remains unclear.
Quantitative genetics in the study of virus-induced disease
2014, Advances in Virus ResearchCitation Excerpt :These experimental systems provide several advantages, including the ability to conduct more invasive and mechanistic studies than are possible in humans, greater control of potentially confounding environmental factors, and the availability of reproducible populations that permit analysis of phenotypic variation over time or across different experimental conditions (e.g., viral doses or different viral variants). These systems include resources developed to interrogate the function of specific genes using either reverse genetics (e.g., knockout mice) or forward genetics (e.g., N-ethyl-N-nitrosourea (ENU) mutagenesis), and though these approaches have played key roles in advancing our understanding of the role the specific host genes play in the pathogenesis of a number of viruses, they have also been reviewed extensively elsewhere (e.g., Davies, Turner, & Klein, 2001; Georgel, Du, Hoebe & Beutler, 2008; Mordstein, Michiels, & Staeheli, 2010; Tecle, White, & Hartshorn, 2005). Therefore, we will only briefly discuss these approaches and will instead focus our discussion on systems tailored to investigate natural genetic variants segregating either between inbred lines of classic lab model organisms or within genetically variant populations (e.g., inbred line screens, F2 and backcrosses, consomic and congenic lines, and genetic reference populations (GRPs); Fig. 4.2).
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population
2013, Infection, Genetics and EvolutionCitation Excerpt :Mbl2 polymorphisms have been associated with low levels of MBL in serum. Individuals homozygous for MBL2 mutation have almost undetectable levels of MBL (⩽10 ng/ml); average levels are reduced to approximately 350 ng/ml in heterozygotes, while MBL concentration reaches over 1600 ng/ml in wild type homozygous individuals (Davies et al., 2001). The decrease in concentration of circulating MBL has been associated with recurrent infections in childhood and possibly in adults.
Single nucleotide polymorphisms in collagenous lectins and other innate immune genes in pigs with common infectious diseases
2011, Veterinary Immunology and ImmunopathologyCitation Excerpt :The MBL1 G(271)T mutation would be consistent with this as it is located within the collagen-like domain and is predicted to disrupt the triple-helix formation of the collagen-like domain (Lillie et al., 2006b) similar to three well-studied coding polymorphisms in the human MBL2 gene (Sumiya et al., 1991; Lipscombe et al., 1992; Madsen et al., 1994) that all independently reduce functional levels of human MBL (Garred et al., 2003). Alternatively, there may be yet undiscovered SNPs, including mutations within the promoter region, similar to those described for MBL-C (Lillie et al., 2007); however there was not much evidence for genetic differences in MBL-A mRNA expression in the liver of Canadian pigs (Lillie et al., 2006a; Lillie et al., 2007), and although MBL-A is expressed in the lung (Davies et al., 2001; Jambo et al., 2007; Phatsara et al., 2007), the regulatory influences are still unknown. There have been numerous association studies examining the effects of human SP-A SNPs on disease susceptibility (Pastva et al., 2007; Sorensen et al., 2007).
Immunology and pathogenesis of childhood TB
2011, Paediatric Respiratory ReviewsCitation Excerpt :However, whether vitamin D deficiency is a result of TB or a contributor to susceptibility remains to be established. Collectins are soluble proteins which include mannose-binding lectin (MBL), surfactant protein A (SP-A) and surfactant protein D (SP-D).9 These form a first line of defence against Mtb by binding to mycobacteria and thereby affecting uptake, killing and innate immune receptor expression.
Pulmonary Manifestations of Hematologic and Oncologic Diseases
2009, Pulmonary Manifestations of Pediatric Diseases