Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Balancing muscle hypertrophy and atrophy

Nature Medicine volume 10, pages 584–585 (2004)Cite this article

The body carefully balances muscle atrophy and muscle hypertrophy in response to stimuli such as starvation or immobilization. Three new studies point to Akt1 phosphorylation of the transcription factor Foxo as a central regulator of this balance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The proteins Akt1 and Foxo at the decision point of atrophy versus hypertrophy.

Erin Boyle

References

  1. Price, S.R. Int. J. Biochem. Cell Biol. 35, 617–628 (2003).

    Article  CAS  Google Scholar 

  2. Sacheck, J.M., Ohtsuka, A., McLary, S.C. & Goldberg, A.L. J. Physiol. (Lond.) (in the press).

  3. Sandri, M. et al. Cell 117, 399–412 (2004).

    Article  CAS  Google Scholar 

  4. Stitt, T.N. et al. Mol. Cell 14, 395–403 (2004).

    Article  CAS  Google Scholar 

  5. Goldberg, A.L. J. Biol. Chem. 244, 3023–3029 (1969).

    Google Scholar 

  6. Massaro, D., DeCarlo Massaro, G., Baras, A., Hoffman, E.P. & Clerch, L.B. Am. J. Physiol. Lung. Cell. Mol. Physiol. 286, L896–L906 (2004).

    Article  CAS  Google Scholar 

  7. Alessi, D.R. et al. EMBO J. 15, 6541–6551 (1996).

    Article  CAS  Google Scholar 

  8. Brunet, A. et al. Cell 96, 857–868 (1999).

    Article  CAS  Google Scholar 

  9. Skurk, C. et al. J. Biol. Chem. 279, 1513–1525 (2004).

    Article  CAS  Google Scholar 

  10. Jiang, Z.Y. et al. Proc. Natl. Acad. Sci. USA 100, 7569–7574 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Center for Genetic Medicine, Children's National Medical Center, Washington, 20010, DC, USA

    Eric P Hoffman & Gustavo A Nader

Authors
  1. Eric P Hoffman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gustavo A Nader
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoffman, E., Nader, G. Balancing muscle hypertrophy and atrophy. Nat Med 10, 584–585 (2004). https://doi.org/10.1038/nm0604-584

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0604-584

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing