Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cytokines and the acute respiratory distress syndrome (ARDS): A question of balance

Nature Medicine volume 3, pages 272–273 (1997)Cite this article

Macrophage inhibitory factor modifies the anti-inflammatory effects of endogenous glucocorticoids in patients with ARDS (pages 320–323).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Donnelly, S.C. et al. Regulatory role for macrophage migration inhibitory factor (MIF) in the acute respiratory distress syndrome (ARDS). Nature Med. 3, 320–323 (1997).

    Article  CAS  Google Scholar 

  2. Hudson, L.D., Milberg, J.A., Anardi, D. & Maunder, R.J. Clinical risks for development of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 151, 293–301 (1995).

    Article  CAS  Google Scholar 

  3. Bachofen, A. & Weibel, E.R. Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am. Rev. Respir. Dis. 116, 589–615 (1977).

    Article  CAS  Google Scholar 

  4. Steinberg, K., Maunder, R.M., Milberg, J., Martin, T.R. & Hudson, L.D. Evolution of bronchoalveolar Cell populations in the adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 150, 113–122 (1994).

    Article  CAS  Google Scholar 

  5. Milberg, J.A., Davis, D.R., Steinberg, K.P. & Hudson, L.D. Improved survival of patients with acute respiratory distress syndrome (ARDS). JAMA 273, 306–309 (1995).

    Article  CAS  Google Scholar 

  6. Pittet, J.F., Mackersie, R., Martin, T.R. & Matthay, M.A. Biological markers of acutelunginjury: prognostic and pathogenetic significance. Am. J. Respir. Crit. Care Med. (in the press).

  7. Donnelly, S.C. et al. lnterleukin-8 and development of adult respiratory distress syndrome in at-risk groups. Lancet 341, 643–647 (1993).

    Article  CAS  Google Scholar 

  8. Goodman, R.B. et al. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 154, 602–611 (1996).

    Article  CAS  Google Scholar 

  9. Pugin, J., Ricou, B., Steinberg, K.P., Suter, P.M. & Martin, T.R. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1β. Am. J. Respir. Crit. Care Med. 153, 1850–1856 (1996).

    Article  CAS  Google Scholar 

  10. Donnelly, S.C. et al. The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. Ann. Intern. Med. 125, 191–196 (1996).

    Article  CAS  Google Scholar 

  11. Bernhagen, J. et al. MIF is a pituitary-derived cytokine that potentiates lethal endotoxemia. Nature 365, 756–759 (1993).

    Article  CAS  Google Scholar 

  12. Calandra, T. et al. MIF is a glucocorticoid-induced modulator of cytokine production. Nature 377, 68–71 (1995).

    Article  CAS  Google Scholar 

  13. Bacher, M. et al. Migration inhibitory factor expression in experimentally induced endotoxemia. Am. J. Pathol. 150, 235–246 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Bernard, G.R. et al. High-dose corticosteroids in patients with the adult respiratory distress syndrome. New Engl. J. Med. 317, 1365–1370 (1987).

    Article  Google Scholar 

  15. Meduri, G.U. et al. Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Chest 105, 1516–1527 (1994).

    Article  CAS  Google Scholar 

  16. McHugh, L. et al. Recovery of function in survivors of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 150, 90–94 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pulmonary and Critical Care Medicine, 111B Seattle VA Medical Center 1660 S. Columbian Way, Seattle, Washington, 98108, USA

    Thomas R. Martin

Authors
  1. Thomas R. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martin, T. Cytokines and the acute respiratory distress syndrome (ARDS): A question of balance. Nat Med 3, 272–273 (1997). https://doi.org/10.1038/nm0397-272

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0397-272

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing