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Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

Nature Medicine volume 4, pages 208–214 (1998)Cite this article

Abstract

The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.

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Authors and Affiliations

  1. Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    Nadine G. Pakker, Marijke T.L. Roos, Frank Miedema & Peter T.A. Schellekens

  2. Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Nadine G. Pakker, Marijke T.L. Roos, Frank Miedema & Peter T.A. Schellekens

  3. Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Daan W. Notermans & Sven A. Danner

  4. Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    Rob J. De Boer

  5. Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Frank De Wolf & Frank Miedema

  6. Abbott Laboratories, Abbott Park, Illinois, 60064, USA

    Andrew Hill

  7. Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom

    John M. Leonard

  8. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Sven A. Danner & Peter T.A. Schellekens

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  1. Nadine G. Pakker
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Correspondence to Frank Miedema.

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Pakker, N., Notermans, D., De Boer, R. et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat Med 4, 208–214 (1998). https://doi.org/10.1038/nm0298-208

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