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A comprehensive genetic map of the human genome based on 5,264 microsatellites

Abstract

THE great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps1–6, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites7,8. We report here the last version of the Généthon human linkage map6. This map consists of 5,264 short tandem (AC/TG)n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.

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References

  1. Dietrich, W. F. et al. Nature Genet. 7, 220–225 (1994).

    Article  CAS  Google Scholar 

  2. Murray, J. C. et al. Science 265, 2049–2070 (1994).

    Article  ADS  CAS  Google Scholar 

  3. Barendse, W. et al. Nature Genet. 6, 227–235 (1994).

    Article  CAS  Google Scholar 

  4. Jacob, H. J. et al. Nature Genet. 9, 63–69 (1995).

    Article  CAS  Google Scholar 

  5. Weissenbach, J. et al. Nature 359, 794–801 (1992).

    Article  ADS  CAS  Google Scholar 

  6. Gyapay, G. et al. Nature Genet. 7, 246–339 (1994).

    Article  CAS  Google Scholar 

  7. Weber, J. L. & May, P. E. Am. J. hum. Genet. 44, 388–396 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Litt, M. & Luty, J. A. Am. J. hum. Genet. 44, 397–401 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lathrop, G. M. & Lalouel, J. M. Am. J. hum. Genet. 36, 460–465 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Walter, M. et al. Nature Genet. 7, 22–28 (1994).

    Article  CAS  Google Scholar 

  11. Spurr, N. K. et al. Eur. J. hum. Genet. 2, 193–252 (1994).

    Article  CAS  Google Scholar 

  12. Gerken, S. C. et al. Am. J. hum. Genet. 56, 484–499 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Elsner, T. I., Albertsen, H., Gerken, S. C., Cartwright, P. & White, R. Am. J. hum. Genet. 56, 500–507 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Plaetke, R. & Schachtel, G. Am. J. hum. Genet. 56, 508–518 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Utah Marker Development Group Am. J. hum. Genet. 57, 619–628 (1995).

  16. Chumakov, I. M. et al. Nature 377, 175–297 (1995).

    CAS  PubMed  Google Scholar 

  17. Hudson, T. J. et al. Science 270, 1945–1954 (1995).

    Article  ADS  CAS  Google Scholar 

  18. Morton, N. E. Proc. natn. Acad. Sci. U.S.A. 88, 7474–7476 (1991).

    Article  ADS  CAS  Google Scholar 

  19. Lathrop, G. M. et al. Genomics 2, 157–164 (1988).

    Article  CAS  Google Scholar 

  20. Matise, T. C., Perlin, M. & Chakravarti, A. Nature Genet. 6, 384–390 (1994).

    Article  CAS  Google Scholar 

  21. Lander, E. S. & Green, P. Proc. natn. Acad. Sci. U.S.A. 84, 2363–2369 (1987).

    Article  ADS  CAS  Google Scholar 

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Dib, C., Fauré, S., Fizames, C. et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380, 152–154 (1996). https://doi.org/10.1038/380152a0

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