Abstract
THE majority of peripheral T cells express a heterodimeric, α/β T-cell receptor, which recognizes specific antigenic peptides bound to self major histocompatibility complex (MHC) molecules, and either the CD4 or CD8 surface markers. An additional subset of T cells1,2, whose physiological function is unknown, express a distinct CD3-associated receptor composed of γ and δ chains1. This subset includes cells lacking both CD4 and CD8 surface markers, which may be involved in autoimmunity3–6. The recognition specificity of the γ/δ receptor is not well characterized and has been defined in only one case to date, a murine cell line which shows MHC-linked specificity7. In this report, we describe the isolation of CD4- CD8-, γ/δ TCR bearing T cell clones from the synovial fluid of a rheumatoid arthritis patient. These T cell clones respond specifically to mycobacterial antigens without MHC restriction.
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Holoshttz, J., Strober, S., Koning, F. et al. Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339, 226–229 (1989). https://doi.org/10.1038/339226a0
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DOI: https://doi.org/10.1038/339226a0
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