Abstract
Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome)1,2. HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans3,4 and apes5. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis6. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CDS surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients.
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Plata, F., Autran, B., Martins, L. et al. AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 328, 348–351 (1987). https://doi.org/10.1038/328348a0
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DOI: https://doi.org/10.1038/328348a0
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