Food, drug, insect sting allergy, and anaphylaxisAllergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006
Section snippets
Study population
Data for this cross-sectional analysis were obtained from NHANES 2005-2006, a national survey designed to assess the health and nutritional status of adults and children in the United States. NHANES used a complex multistage design to sample the civilian, noninstitutionalized US population. To ensure adequate sample sizes of certain subgroups of the population, NHANES 2005-2006 oversampled persons of low income, adolescents (12-19 years), elderly subjects (≥60 years of age), African Americans,
Results
In NHANES 2005-2006 the prevalence of diagnosed hay fever was 11.3%, and 6.6% reported current hay fever. One third of the participants (33.9%) had diagnosed allergies, and 23.5% had current allergies. The weighted characteristics of the study population are presented in Table I. The prevalence of the primary outcomes (current hay fever and current allergies) varied significantly based on sociodemographic variables (Table I). The prevalence increased with age until it peaked in the fourth
Discussion
NHANES 2005-2006 provided a unique opportunity to evaluate how levels of total IgE and allergen-specific IgE relate to allergic conditions and symptoms in the US population. None of the previous NHANES studies have examined both qualitative and quantitative patterns of atopy in relation to allergy-related outcomes. Moreover, this many allergens have been examined in only a few large-scale European studies.16, 17, 18 Although several studies have investigated allergic outcomes in relation to
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Supported by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences.
Disclosure of potential conflict of interest: S. J. Arbes is employed by Rho, Inc, and has a contract with the National Institute of Dental and Craniofacial Research/National Institutes of Health. The rest of the authors have declared that they have no conflict of interest.