Reviews and feature articleIncreased risk of serious pneumococcal disease in patients with asthma
Section snippets
Methods
The study was approved by the Institutional Review Boards of both Mayo Clinic and Olmsted Medical Center. This is a population-based, retrospective case-control study of 3941 records from a Rochester, Minnesota, population from 1964 through 1983 designed to assess whether there is a higher incidence of SPD among persons with asthma. Among the 3941 study participants, the diagnosis of asthma had been previously determined as part of another study by using a structured algorithm and predetermined
Study subjects
The characteristics of the subjects and the relationship between individual risk factors and SPD are summarized in Table I. We identified 174 confirmed SPD cases, of which 16% (n = 28), 22% (n = 38), and 62% (n = 108) had IPD, IPD with pneumococcal pneumonia, and pneumococcal pneumonia, respectively. Of the 174 subjects with SPD, 51% were male, and 94% were white. The median and mean ages at the index date of SPD were 65 and 57 years, respectively. Only 21 (12%) cases were younger than 18
Discussion
In our study SPD was associated with a prior history of asthma in adults, suggesting that asthma increased the risk for SPD. Our study results are consistent with the study findings reported by Talbot et al.8 They reported an adjusted OR for asthma status of 2.4 (95% CI, 1.9-3.1), which is comparable with our adjusted OR (OR, 2.4; 95% CI, 0.9-6.6; P = .09) for all subjects. The effect size for adult subjects in our study was still increased and significant after adjustment for smoking exposure,
References (32)
- et al.
Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
Lancet
(2006) - et al.
Potential influence of migration bias in birth cohort studies
Mayo Clin Proc
(1998) - et al.
Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan. IV. Natural history
J Allergy Clin Immunol
(1974) - et al.
Childhood Asthma and Measles Vaccine Response
Ann Allergy Asthma Immunol
(2006) - et al.
Immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine in healthy children and in children at increased risk of pneumococcal infection
Vaccine
(1995) - et al.
Clearance of Mycoplasma Pneumoniae is impaired in mice with established allergic airway inflammation
J Allergy Clin Immunol
(2007) - et al.
Summary of health statistics for US adults: National Health Interview Survey, 2005. Vital & Health Statistics-Series 10: Data from the Health Survey
(2006) Anonymous. Forecasted state-specific estimates of self-reported asthma prevalence—United States, 1998
MMWR Morb Mortal Wkly Rep
(1998)- World Health Organization. Fact sheet for asthma. August, 2005; Fact Sheet for Asthma N307. Available at:...
- et al.
Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey
Thorax
(2004)
A community-based study of the epidemiology of asthma: incidence rates, 1964-1983
Am Rev Respir Dis
Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995-1998: opportunities for prevention in the conjugate vaccine era
JAMA
Asthma as a Risk Factor for Invasive Pneumococcal Disease
N Engl J Med
A community-based study of the epidemiology of asthma: incidence rates, 1964-1983
Am Rev Respir Dis
The patient record in epidemiology
Sci Am
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Supported by a National Institutes of Health grant (R01 AI 56133) from the National Institute of Allergy and Infectious Diseases.
Disclosure of potential conflict of interest: B. P. Yawn is on the advisory board for Schering-Plough; is on the speakers' bureau for AstraZeneca; has received research support from Schering-Plough, AstraZeneca, and Pfizer; and has served as a member of the Minnesota Asthma Coalition and EPR-3 National Heart, Lung, and Blood Institute. P. Wollan has received research support from AstraZeneca and the Agency for Healthcare Research and Quality. R. M. Jacobson has received research support from PSC Corp. The rest of the authors have declared that they have no conflict of interest.