Asthma diagnosis and treatmentThe relationship of breast-feeding, overweight, and asthma in preadolescents
Section snippets
Methods
This was a nested case-control study that included 246 children with pediatric allergist–diagnosed asthma and 477 controls without asthma at 8 to 10 years of age. Cases and controls were recruited from the same cohort of children born in 1995 in the province of Manitoba, Canada, after parent response to a mailed survey on child health when these children were 8 to 10 years of age. The 1995 cohort was identified from the records of the Manitoba Health Services Insurance Plan, which was a
Results
Sex, maternal asthma, paternal asthma, aboriginal origin, passive smoking at birth, residence location, and family income were significantly associated with exclusive breast-feeding and/or overweight and/or asthma (Table I) and thus were included in the multivariate logistic regression analyses. No significant associations were found between low birth weight or exposure to pets and exclusive breast-feeding, overweight, or asthma, and these factors were excluded from multivariate models.
In
Discussion
In our study, short duration of exclusive breast-feeding had a marginal association with asthma in preadolescents after adjustment for overweight and other covariates, which was consistent with findings in children at a younger age.3, 4, 5, 6, 7, 29 More interestingly, we found that combined exclusive breast-feeding <12 weeks and overweight was significantly associated with asthma. Because exclusive breast-feeding <12 weeks was closely associated with overweight in our study and that of others,
References (42)
- et al.
The role of breast-feeding in the development of allergies and asthma
J Allergy Clin Immunol
(2005) - et al.
Breast-feeding and the prevalence of asthma and wheeze in children: analyses from the Third National Health and Nutrition Examination Survey, 1988-1994
J Allergy Clin Immunol
(2003) - et al.
Breast-feeding reduces the risk of asthma during the first 4 years of life
J Allergy Clin Immunol
(2004) - et al.
Maternal asthma, infant feeding, and the risk of asthma in childhood
J Allergy Clin Immunol
(2002) - et al.
Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
Lancet
(2002) - et al.
The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age
J Allergy Clin Immunol
(2005) - et al.
Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age
Chest
(2005) - et al.
Balancing susceptibility to infection and autoimmunity: a role for leptin?
Trends Immunol
(2002) The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life
Paediatr Respir Rev
(2004)- et al.
Maternal obesity and breast-feeding success in a rural population of white women
Am J Clin Nutr
(1997)
Tucson Children's Respiratory Study: 1980 to present
J Allergy Clin Immunol
Host defense benefits of breastfeeding for the infant: effect of breastfeeding duration and exclusivity
Pediatr Clin North Am
Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations
Allergy
Breastfeeding and asthma in young children: findings from a population-based study
Arch Pediatr Adolesc Med
Breast feeding and allergic diseases in infants: a prospective birth cohort study
Arch Dis Child
Relation between breastfeeding and the prevalence of asthma: the Tokorozawa Childhood Asthma and Pollinosis Study
Am J Epidemiol
The association of prolonged breastfeeding and allergic disease in poor urban children
Eur Respir J
Breastfeeding, soluble CD14 concentration in breast milk and risk of atopic dermatitis and asthma in early childhood: birth cohort study
Clin Exp Allergy
Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood
Thorax
Risk of overweight among adolescents who were breastfed as infants
JAMA
Inverse association of overweight and breast feeding in 9 to 10-y-old children in Germany
Int J Obes Relat Metab Disord
Cited by (47)
Babies Galore; Or recent findings and future perspectives of pregnancy cohorts with a focus on immunity
2015, Journal of Reproductive ImmunologyIn reply
2013, Mayo Clinic ProceedingsChildhood Overweight/Obesity and Asthma: Is There a Link? A Systematic Review of Recent Epidemiologic Evidence
2013, Journal of the Academy of Nutrition and DieteticsCitation Excerpt :One cross-sectional investigation indicated as a secondary important finding that a shorter duration of breastfeeding (<2 months) combined with at least overweight status (BMI z score ≥1)86 was significantly associated with asthma (prevalence ratio 1.53, 95% CI 1.11 to 2.09).36 Among the four recent case-control studies,64-67 three64-66 did not identify an association between high body weight (at least overweight status) and asthma symptoms (Table 2). Only one case-control study67 showed that BMI was significantly higher in patients with asthma compared with healthy subjects (P<0.002).
Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes
2012, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Nasal swabs were tested for each virus, and the sensitivity for detection by means of RT-PCR was 102 to 103 copies of virus-specific nucleic acid within a specimen.19 This study included 723 children and their parents who were recruited from a population-based sample of 16,320 children born in Manitoba, Canada, in 1995.29-31 A total of 3,586 children participated in a survey in 2002, of whom 392 had asthma, 192 had hay fever or food allergy, and 3,002 had none of these conditions.
Probiotics in the Development and Treatment of Allergic Disease
2012, Gastroenterology Clinics of North AmericaCitation Excerpt :The shift of emphasis in the hygiene hypothesis has thus evolved from acute infection protecting from atopic disease3,4 to a balanced gut microbiota, the earliest and most massive source of microbial exposure, protecting from the chronic inflammatory conditions, collectively characterized as Western lifestyle diseases.1 Indeed, environmental changes in the industrialized world reducing microbial contact at an early age have occurred concomitant with the growing epidemic of atopic eczema, allergic rhinoconjunctivitis, and asthma, but also with diseases phenotypically as different as inflammatory bowel disease and type I diabetes, and obesity with its comorbidities.5–7 All in all, the development of these conditions points to a failure to generate and maintain a balanced host-microbe interaction, resulting in a tolerogenic milieu in the mucosae, the interface between the internal and external environments of the host.
Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren
2010, Journal of Allergy and Clinical ImmunologyCitation Excerpt :In the study by Sears et al,4 51% of the children were not breast-fed or were breast-fed less than 4 weeks, and the remaining 49% were breast-fed 4 weeks or more in comparison with the current study, in which almost all children were breast-fed to some extent. Moreover, some studies provide evidence of effect modification by sex and parental history of allergic disease.27,28 No such effect modification was evident in our study.
Supported by the Canadian Institutes of Health Research, AllerGen NCE Inc, the National Training Program in Asthma and Allergy, and the Manitoba Institute of Child Health. Dr Mai is the recipient of a postdoctoral fellowship award from the Canadian Institutes of Health Research.
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.