Asthma diagnosis and treatmentInner City Asthma Study: Relationships among sensitivity, allergen exposure, and asthma morbidity
Section snippets
Methods
The ICAS enrolled 937 children (of 1059 children screened) age 5 to 11 years and their caretakers from 7 metropolitan inner city areas in the United States. In a fully crossed factorial design, study participants were randomized to receive an environmental allergen reduction intervention, an intervention providing bimonthly feedback regarding the child's clinical status to the children's primary care physician, both interventions, or neither intervention. The sample size was chosen on the basis
Results
Of 1059 children skin tested, 994 (93.9%) had a positive skin test result to 1 or more of the allergens used in the testing. Of these 994 children, 937 (94.3%) successfully completed the baseline home evaluation and were enrolled. Table I describes the characteristics of all of the participants and their homes. As shown, the children in the control group, the only group examined in the morbidity analysis, had characteristics that were not appreciably different from the entire population
Discussion
Results from the ICAS demonstrate that skin test reactivity and allergen levels vary widely depending on location in the country. The majority of enrolled children were allergic to dust mite and/or cockroach allergens, and positive skin test responses were related to the levels of these allergens in the child's bedroom. In addition, we found that children who were allergic to cockroach and exposed to cockroach allergen had more asthma symptoms, more school days missed because of asthma, and
References (22)
- et al.
Risk factors for asthma in inner-city children
J Pediatr
(1992) - et al.
Socioeconomic status and race as risk factors for cockroach allergen exposure and sensitization in children with asthma
J Allergy Clin Immunol
(1996) - et al.
Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma
J Allergy Clin Immunol
(1998) - et al.
The relationships among environmental allergen sensitization, allergen exposure, pulmonary function and bronchial hyperresponsiveness in the Childhood Asthma Management Program
J Allergy Clin Immunol
(1999) - et al.
Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relation to sensitization and asthma among children living in Los Alamos, New Mexico
J Allergy Clin Immunol
(1995) - et al.
House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program
J Allergy Clin Immunol
(2001) - et al.
Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: results from the national survey of lead and allergens in housing
J Allergy Clin Immunol
(2004) - et al.
Sensitization, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
Lancet
(2001) - et al.
Changing patterns of asthma hospitalization among children: 1979 to 1987
JAMA
(1990) - et al.
Recent trends in the prevalence and severity of childhood asthma
JAMA
(1992)
Clearing the air: asthma and indoor exposures
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Supported by grants AI-39769, AI-39900, AI-39902, AI-39789, AI-39901, AI-39761, AI-39785, and AI-39776 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, and the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, and by grant M01 RR00533 from the National Center for Research Resources.