Original articleGeneral thoracicSurvival After Recurrent Nonsmall-Cell Lung Cancer After Complete Pulmonary Resection
Section snippets
Material and Methods
Thirteen hundred sixty-one consecutive patients who successfully underwent complete surgical resection for NSCLC at Mayo Clinic in Rochester, Minnesota, from January 1997 to December 2001 formed the initial study cohort. The Epidemiology and Genetics of Lung Cancer Research Program at the Mayo Clinic (Rochester, Minnesota) was utilized for collection of follow-up information. This program identifies and prospectively follows all patients at Mayo Clinic Rochester with a pathologic diagnosis of
Results
Of the 1,361 initial cohort patients, complete follow-up was achieved in 1,073 patients (79%). Median follow-up was 23.3 months (range, 1.6 to 81.7). To check for possible bias in the patient selection process due to incomplete follow-up in the remaining 288 patients, baseline characteristics (age, sex, smoking status, lung cancer stage and histology, and lung cancer treatment) were compared between patients with complete (n = 1,073) and incomplete follow-up (n = 288). There was no significant
Comment
Our investigation of the predictors of PRS led to the identification of seven independent prognostic factors (Table 4). Four of these involved the presentation of IR, including disease-free interval, site of recurrence, symptoms, and ECOG-PS. Two involved the utilization of neoadjuvant chemotherapy or adjuvant radiation therapy at the time of initial surgical resection. Finally, treatment for recurrent disease was a prognostic factor.
Our results demonstrating the presence of symptoms as a
References (28)
- et al.
Incidence of local recurrence and second primary tumors in resected stage I lung cancer
J Thorac Cardiovasc Surg
(1995) - et al.
Gender differences in non-small cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002
Ann Thorac Surg
(2004) - et al.
The impact of cigarette smoking on quality of life after diagnosis of lung cancer
Chest
(2004) Revisions in the international system for staging lung cancer
Chest
(1997)- et al.
Multiple primary lung cancers
J Thorac Cardiovasc Surg
(1975) - et al.
Relevance of an intensive postoperative follow-up after surgery for non-small cell lung cancer
Ann Thorac Surg
(2000) - et al.
Is follow-up of lung cancer patients after resection medically indicated and cost-effective?
Ann Thorac Surg
(1995) Confirmation of a prognostic index for patients with inoperable non-small cell lung cancer
Radiother Oncol
(1997)- et al.
Postrecurrent survival of patients with non-small cell lung cancer undergoing a complete resection
J Thorac Cardiovasc Surg
(1994) - et al.
Prognostic factors in non-small cell lung cancer: a decade of progress
Chest
(2002)
Local recurrence after complete resection for non-small-cell carcinoma of the lung: significance of local control by radiation treatment
J Thorac Cardiovasc Surg
Multiple primary lung cancers
J Thorac Cardiovasc Surg
Benefits of resection for metachronous lung cancer
J Thorac Cardiovasc Surg
Successful treatment of solitary extracranial metastases from non-small cell lung cancer
Ann Thorac Surg
Cited by (261)
Prognosis of patients with recurrent nonsmall cell lung cancer who received the best supportive care alone
2024, Current Problems in SurgeryIntegration of New Systemic Adjuvant Therapies for Non-small Cell Lung Cancer: Role of the Surgeon
2023, Annals of Thoracic SurgeryEconomic Burden of Recurrence Among Resected Medicare Patients With Early Stage NSCLC
2023, JTO Clinical and Research ReportsAdvances in the treatment of postoperative recurrence of non–small cell lung cancer and their impact on survival in Asian patients
2023, Journal of Thoracic and Cardiovascular Surgery