Original article: general thoracicHistological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung
Section snippets
Patients and methods
The case notes of all patients who underwent a surgical resection for nonsmall cell lung cancer between January 1991 and December 1997 at Nottingham City Hospital were reviewed retrospectively. All operations were performed by the same team of four thoracic surgeons who used similar preoperative and postoperative management. None of these patients underwent any preoperative or postoperative chemotherapy or radiotherapy. Before thoracotomy, all patients underwent an assessment for fitness for
Patient and tumor characteristics
Of the 98 patients, 64 were male and 24 were female with a mean age of 61.8 years (range, 45 to 78). Fifty-eight patients underwent a pneumonectomy, and 40 underwent either a lobectomy, bilobectomy, or sleeve lobectomy. A summary of the histologic characteristics of the specimens is shown in Table 1. Details of the patients' nodal involvement are listed in Table 2.
Univariate analysis
Of the 98 potentially curative lung resections, a total of 43 patients survived for a 5-year period after operation, representing
Comment
Under the TNM-based staging system for nonsmall cell lung cancer T1N1ML0, T2N1ML0, and T3N0ML0 tumors are jointly classified as stage II disease, with a further subdivision into stage IIA (for T1 tumors) and stage IIB (for T2 and T3 tumors) [15]. Although this staging system provides an anatomical classification of lung tumors, its secondary purpose is to allow the prognostic stratification of patients into homogenous groups after surgery 15, 16. Our study, however, in common with previously
Acknowledgements
The authors would like to thank Lynda Beggs for her assistance with data collation and analysis. In addition, we gratefully acknowledge the contribution of Fayek Salama in the management of these patients.
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