Reassessment of FDG uptake in tumor cells: High FDG uptake as a reflection of oxygen-independent glycolysis dominant energy production
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Cited by (19)
Benign Cutaneous and Subcutaneous Lesions on FDG-PET/CT
2017, Seminars in Nuclear MedicineCitation Excerpt :The most common etiologies for increased FDG uptake in the skin or subcutaneous tissues are inflammatory or infectious (Table 1). FDG is a glucose analog with a metabolic pathway similar to that of glucose, including uptake by cell surface transporter proteins (mainly GLUT-1) and phosphorylation by hexokinase.1 In 1923, Otto Heinrich Warburg suggested that most malignant cells produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol.
The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [<sup>18</sup>F]-fluoro-deoxy-glucose
2015, Radiotherapy and OncologyCitation Excerpt :Beyond these applications, it has been suggested in the literature that 18F-FDG uptake could also indirectly reflect the oxygenation status of tumors, a major factor involved in resistance to radiation therapy. This assertion has already been discussed in several studies providing discordant results [12–21]. Here, we found in both tumor models an inverse relationship between 18F-FDG uptake and pO2 values, a behavior that is rather comparable to what has been found with several nitroimidazoles such as EF3 [22] and 18F-FAZA [23].
Investigation of the interaction of pig muscle lactate dehydrogenase with acidic phospholipids at low pH
2006, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Also, in plasma membranes of Alzheimer disease brain cells from different regions of the brain, the level of serine glycerolphospholipids is significantly higher than that in control brains [19]. It is a well-known fact that in cancer tissue a dramatic increase in glycolysis is observed, which is likely induced by increased hypoxia and increase need for ATP generation [20,21]. The mechanisms of tumor acidity have not been solved in detail.
Mass effect of injected dose in small rodent imaging by SPECT and PET
2005, Nuclear Medicine and BiologyImpact of proliferative activity and tumorigenic conversion on mitochondrial function of fibroblasts in 2D and 3D culture
2001, Cell Biology International