Increased resting energy expenditure is related to plasmaTNF-α concentration in stable COPD patients

doi:10.1016/S0261-5614(98)80023-X

Clinical Nutrition

Volume 18, Issue 5, October 1999, Pages 269-274

https://doi.org/10.1016/S0261-5614(98)80023-X Get rights and content

Abstract

The objective of this study was to test whether increased resting energy expenditure (REE) in chronic obstructive pulmonary disease (COPD) patients is related to increased cost of breathing and/or to increased cytokine production.

In 36 non-inflammatory (CRP: 17.6 ± 13.1 mg.l⁻¹, mean ± SD; orosomucoid: 0.71 ± 0.18 g.l⁻¹), non-malnourished(BMI: 23.6 ± 4.3 kg. m⁻²), clinically stable, non severely hypoxic COPD patient (60.5 ± 8.9 years) we measured REE, pulmonary function and plasma cytokine concentrations (TNF-α, IL1 and IL6). REE was increased by 10 ± 11% (P < 0.001) above predicted values. Plasma TNF-α concentration was increased in all patients (mean value 26.3 ± 14.3 pg.ml⁻¹). Excess REE (with respect to values predicted by Harris-Benedict equations) was correlated with plasma TNF-α concentration (P < 0.005), but not with the degree of airway obstruction, lung overinflation, or with oxygen cost of breathing. Theophylline treatment resulted in a significant increase in REE by 15%.

In conclusion: non-malnourished, clinically stable, non-severely hypoxic COPD patients display anincreased REE that is related with plasma TNF-α concentration (without apparent systemic inflammation) and to theophylline treatment, but that is independent of parameters of respiratory function

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Original articleIncreased resting energy expenditure is related to plasmaTNF-α concentration in stable COPD patients

Abstract

Chest

Clin Nutr

Chest

Chest

Am J Clin Nutr

Chest

Lancet

Metabolism

Am J Clin Nutr

J Immunol Meth

Statement standards for the diagnosis and care of patients with chronic obstructive pulmonary disease

Am J Respir Crit Care Med

Body weight in COPD

Am Rev Respir Dis

Nutitional status and mortality in chronic obstructive pulmonary disease

Am J Respir Crit Care Med

Weight changes in the terminal stages of chronic obstructive pulmonary disease

Am Rev Respir Dis

Nutritional status and bacterial binding in the lower respiratory tract in patients with chronic tracheotomy

Ann Intern Med

Oxygen consumption of the respiratory muscle in normal and malnourished patients with chronic obstructive pulmonary disease

Am Rev Respir Dis

Metabolic rate and weight loss in chronic obstructive pulmonary disease

J Parent Enter Nutr

Energy balance in chronic obstructive pulmonary disease

Am Rev Respir Dis

Comparison between basal metabolic rate and diet-induced thermogenesis in different types of chronic obstructive pulmonary disease

Clin Sci

The daily energy expenditure in stable chronic obstructive pulmonary disease

Am J Respir Crit Care Med

Resting energy expenditure and nutritional state of patients with increased oxygen cost of breathing due to emphysema, scoliosis and thoracoplasty

Thorax

The oxygen consumption and efficiency of the respiratory muscles in health and emphysema

J Clin Invest

Original article
Increased resting energy expenditure is related to plasmaTNF-α concentration in stable COPD patients