Trends in Pharmacological Sciences
ViewpointEosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development
References (70)
- Korsgren, M., Erjefält, J. S., Erjefält, I., Sundler, F. and Persson, C. G. A. Am. J. Respir. Crit. Care Med. Abstr....
- et al.
Am. J. Respir. Crit. Care Med.
(1996) J. Clin. Exp. Allergy
(1996)- et al.
Immunol. Today
(1995) - et al.
Am. J. Pathol.
(1995) - et al.
Am. Rev. Respir. Dis.
(1992) Thorax
(1993)- et al.
Lab. Invest.
(1990) - et al.
Int. Arch. Allergy Immunol.
(1996) Eur. Respir. Rev.
(1994)
J. Am. Med. Assoc.
Dtsch. Arch. Klin. Med.
Acta Med. Scand.
J. Exp. Med.
Biochem. Biophys. Res. Commun.
Cell Tissue Res.
Microvasc. Res.
J. Appl. Physiol.
J. Exp. Med.
Cell. Immunol.
Immunol. Today
Am. Rev. Respir. Dis.
Lancet
Am. Rev. Respir. Dis.
Medicine
J. Immunol.
J. Immunol.
Am. J. Pathol.
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Eosinophils: Focus on DNA extracellular traps
2022, Life SciencesCitation Excerpt :Human eosinophils can undergo cytolysis with intact granule release in vivo [24,25] and in vitro [25]. Over the years, the presence of membrane-bound free intact secondary granules, with their unique crystalline cores, has been documented in biopsies, tissues and secretions of different diseases, such as asthma, rhinitis, eosinophilic esophagitis and other eosinophil-associated diseases [26–30]. This curious frequent observation was, for a long time, underexplored and, for many, considered an artifact until findings in vitro challenged this point [25,31–34].
How to detect eosinophil ETosis (EETosis) and extracellular traps
2021, Allergology InternationalCitation Excerpt :Indeed, eosinopilopoietic cytokines such as GM-CSF and IL-5 markedly prolong the viability of isolated blood eosinophils in vitro. Conversely, cytolysis of eosinophils that generate extracellular free granules has been observed in inflamed tissues for more than 100 years.3 This paradoxical phenomenon of in vitro and in vivo observations can be explained by active non-apoptotic cell death.
Biology of Eosinophils
2014, Middleton's Allergy: Principles and Practice: Eighth EditionEosinophil Secretory Functions
2013, Eosinophils in Health and DiseaseEosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans
2013, BloodCitation Excerpt :Free extracellular eosinophil granules have been documented in diverse diseases, including atopic dermatitis and nasal allergy, and they have been correlated with the severity of urticaria.4,6 Since the late 1800s, free eosinophil granules have been noted in the sputum of asthmatics, and clusters of free eosinophil granules (termed “Cfegs”) have been documented in human asthma and experimental guinea pig models of asthma.7 The release of intact, membrane-bound granules occurs via an enigmatic mode of eosinophil “degranulation” that arises from the cytolysis of eosinophils.
Eosinophil Secretory Functions
2012, Eosinophils in Health and Disease
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Scientific adviser, Preclinical R&D, Astra Draco, Lund, Sweden