Research LettersHIV seroprevalence by anonymous testing in patients with Mycobacterium tuberculosis and in tuberculosis contacts
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FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: Evidence through a meta-analysis
2021, Infection, Genetics and EvolutionCitation Excerpt :Although, one third of the population of the world is infected with the bacillus but only a tiny percentage of the people may progress to active TB disease (Delgado et al., 2002). A number of factors are associated with the susceptibility of TB such as- environmental (Hillerdal, 2000), genetic (Newport and Nejentsev, 2004), and HIV infection (Bowen et al., 2000; Raghavan et al., 2012) etc. A number of studies were performed to determine the role of single nucleotide polymorphisms (SNPs) in the susceptibility of TB like- natural resistance–associated macrophage protein 1 (NRAMP1) gene (Borgdorff, 1998), interleukin (IL) genes (Diagbouga et al., 1999; Wilkinson et al., 1999), vitamin D receptor (VDR) genes (Selvaraj et al., 2004a), and tumor necrosis factor (TNF) genes (Selvaraj et al., 2001).
Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics
2019, Journal of InfectionCitation Excerpt :Firstly, the low frequencies of documented virological, immunological and clinical failures observed overall support the continual utilization of the affordable, heat-stable formulations of LPV/r or ATV/r combined with dual NRTIs.2 Secondly, consideration should be given to the wider availability and use of rifabutin for the treatment of tuberculosis in LMICs particularly among patients on 2nd line ART given the adverse pharmacokinetic interactions of rifampicin on exposure to boosted PI,21,22 the high burden of tuberculosis in LMICs23 and the demonstrable favorable PK interactions between rifabutin and LPV/r in both adults and children.24,25 Alternatively, second-line ART regimens based on dolutegravir, with manageable interaction with rifampin, should be considered.26
Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran
2017, Genomics DataCitation Excerpt :Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. However, a relatively small proportion of people infected with Mycobacterium tuberculosis will develop TB [45–48]. Host genetic factors can determine differences in the susceptibility and/or resistance to infections, as well as in the clinical patterns of diseases.
An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population
2015, International Journal of Infectious DiseasesCitation Excerpt :Although it is estimated that one third of the world's population has been infected with the bacillus which may cause TB, a relatively small proportion of the people (10%) infected with bacillus will progress to active TB disease.2 It is suggested that the susceptibility to TB is multifactorial disease, influenced by many factors including HIV infection, environmental and host genetic factors.19–22 Recently, various studies have been reporting that host genetic factors may play an important role in the susceptibility to TB.
Human immunodeficiency virus testing among patients with tuberculosis at a University Hospital in Taiwan, 2000 to 2006
2009, Journal of the Formosan Medical Association