Journal of Allergy and Clinical Immunology
Structural consequences of airway inflammation in asthma☆,☆☆
Section snippets
Airway wall thickness and bronchial hyperreactivity
In chronic obstructive disorders, bronchial hyperreactivity appears to be correlated with airway caliber; histamine or methacholine challenge appears to be associated with the prechallenge FEV1 level.14, 15 However, both studies differed because there was a linear relationship between baseline FEV1 level and response to methacholine in patients with asthma and patients with chronic bronchitis, although the response to methacholine was greater in the patient with asthma than in the patients with
Abnormal pulmonary function in patients with asthma
For decades, asthma has been considered a completely reversible obstructive disease; in most patients, complete reversibility of long-standing abnormal spirometric measurements, such as FEV1 level, may be observed after bronchodilators and/or a course of corticosteroids. On the other hand, many patients with asthma (both children and adults) have evidence of residual airway obstruction,33, 34, 35 which may even be noticed in some asymptomatic patients.36 However, this irreversible component of
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2015, Advances in ImmunologyCitation Excerpt :Bidirectional interaction between MCs and Eos, mediated by soluble mediators (Piliponsky, Gleich, Nagler, Bar, & Levi-Schaffer, 2003; Vliagoftis et al., 2004) and physical means (Elishmereni et al., 2011), has been investigated and described by us and termed the “Allergic Effector Unit” (AEU). Moreover, MCs and Eos are central cells for the tissue remodeling consequences of AI, by interacting with various structural cells such as epithelial cells, endothelial cells, and smooth muscle cells and notably with the fibroblasts (FBs) that in turn also influence MCs and Eos behavior (reviewed in Bento & Hershenson, 1998; Vignola, Chanez, Bonsignore, Godard, & Bousquet, 2000). Therefore, another important cross-talk between MCs, Eos, and FBs takes place that influences not only tissue remodeling but also the activity of MCs and Eos (Bainbridge, 2013).
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Reprint requests: Pr Jean Bousquet , MD, PhD, Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire, 34295 Montpellier Cedex 5, France.
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0091-6749/2000 $12.00 + 0 1/0/100089