The Regulatory Influence of Activated T Cells on B Cell Responses to Antigen

doi:10.1016/S0065-2776(08)60683-5

Advances in Immunology

Volume 15, 1972, Pages 1-94

https://doi.org/10.1016/S0065-2776(08)60683-5 Get rights and content

Publisher Summary

This chapter discusses the intimate mechanisms of the regulation of antibody responses by T cells, the significance of these phenomena for the regulatory processes of the immune system, and their possible implication for the pathogenesis of various immunopathological states. The chapter adheres to popular terminology to refer to the two distinct classes of immunocompetent lymphocytes—T cells and B cells. The T cells are lymphocytes that have differentiated under the influence of the thymus and are responsible for mediating cellular immune reactions—such as delayed hypersensitivity and transplantation reactions. These cells participate in the development of humoral immunity but are not capable of secreting humoral antibodies. Because T cells stimulated by antigen respond by a clonal expansion and differentiation; and by being activated to perform their specific function, the former is elected as “educated T cells” and the latter as “activated T cells.” Activated T cells may result from stimulation by agents other than specific antigen. The B cells are lymphocytes that have differentiated under the influence of the bursa or its analog in mammals and ultimately become the effector cells in humoral immunity by the virtue of synthesizing and secreting immunoglobulin antibodies.

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The Regulatory Influence of Activated T Cells on B Cell Responses to Antigen

Publisher Summary

Lancet

Lancet

Lancet

Lancet

Lancet

Cell. Immunol.

Lancet

Cell. Immunol.

Aust. J. Sci.

“The Clonal Selection Theory of Acquired Immunity.”

Cold Spring Harbor Symp. Quant. Biol.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

Transplant. Rev.

“The Specificity of Serological Reactions,”

J. Exp. Med.

Aust. J. Exp. Biol. Med. Sci.

Nature (London)

Annu. Rev. Microbiol.

Aust. J. Exp. Biol. Med. Sci.

J. Exp. Med.

Aust. J. Exp. Biol. Med. Sci.

J. Immunol.

Physiol. Rev.

Int. Arch. Allergy Appl. Immunol.

J. Exp. Med.

J. Exp. Med.

J. Exp. Med.

J. Pediat.

Nature (London)

Proc. Roy. Soc., Ser. B

Proc. Soc. Exp. Biol. Med.

Proc. Soc. Exp. Biol. Med.

J. Exp. Med.

Nature (London)

Transplantation

Ann. N. Y. Acad. Sci.

Nature (London)

Lancet

Nature (London)

Transplantation

Clin. Exp. Immunol.