Specificity, pathogenecity, and clinical value of antiendothelialcell antibodies
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Cited by (78)
Agonistic antibodies in systemic sclerosis
2018, Immunology LettersCirculating platelet aggregates damage endothelial cells in culture
2017, Journal of Surgical ResearchCitation Excerpt :AECAs are a heterogeneous group of autoantibodies, associated with several diseases characterized by immune-mediated vascular damage such as systemic lupus erythematosus,24 systemic sclerosis,25 rheumatoid arthritis,26 and Wegener's granulomatosis.27 These are valuable as markers of disease activity, and play a major role in the pathophysiology of associated diseases, especially by inducing endothelial cell activation or apoptosis.28–31 Circulating thrombi and damaged/injured endothelium might mutually influence the presence and formation of each other, such presence of CECs and ECDP might give rise to AECA, and the resultant autoantibodies might affect endothelial progenitor cells (EPCs)–mediated repairing mechanisms i.e. angiogenesis and neovascularization.
Cardiovascular disease due to accelerated atherosclerosis in systemic vasculitides
2013, Best Practice and Research: Clinical RheumatologySudden sensorineural hearing loss: An autoimmune disease?
2011, Autoimmunity ReviewsCitation Excerpt :Anti-endothelial cell antibodies (AECAs) are a heterogeneous group of antibodies directed against endothelial cells. They have been detected in several diseases that all involve vessel wall damage [84]. There is an increasing body of evidence that AECAs might play a role in triggering autoimmune vascular diseases.
Antiendothelial cell antibody levels in patients with masked hypertension
2008, International Journal of CardiologyCitation Excerpt :Although probably of limited value in disease diagnosis, the detection of these antibodies may be valuable in following disease activity. In several diseases such as systemic lupus erythematosus and systemic vasculitis, high AECA titers are found during active disease whereas lower titers or disappearance of AECA have been reported during remission [26]. AECA possesses functional properties, such as endothelial cell activation leading to the induction of a pro-inflammatory/pro-coagulant phenotype of the endothelial cells.
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Dr. Cohen Tervaert is supported by a grant from the RoyalNetherlands Academy of Arts and Sciences.