Original contributionRole of transforming growth factor-β1 and decorin in development of central fibrosis in pulmonary adenocarcinoma
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Cited by (25)
Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology
2014, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Notably, these findings were independently confirmed by a recent study demonstrating that decorin can be cleaved by MMP-8 and lead to a reduction in tumor growth and lung metastasis formation by MDA-MB-231 (4175) breast cancer cells by inhibiting TGF-β signaling and reducing miR-21 levels [177]. The anti-tumoral effects of decorin in lung cancer were already emphasized in earlier studies showing that in patients with T1 pulmonary adenocarcinoma, TGF-β1 is primarily associated with central fibrosis [178]. Additionally, when central fibrosis was composed of proliferative connective tissue with weak staining for decorin, cancer cells showed intense staining for TGF-β1 while when central fibrosis was composed of old fibrotic tissue with dense staining for decorin, cancer cells showed weak staining for TGF-β1 suggesting the role of decorin as a TGF-β1 negative regulator in pulmonary adenocarcinoma [178].
The Role of Transforming Growth Factor β in Lung Development and Disease
2004, ChestCitation Excerpt :In addition, several other cytokines, such as tumor necrosis factor (TNF)-α,40 keratinocyte growth factor,41 angiotensin II,42 and interleukin 1043 may exhibit profibrotic effects via the TGFβ pathway. An increased expression of TGFβ messenger RNA83235444546 and protein893233354446474849 as well as the type II receptor32 has been documented during the phase of tissue remodeling in several forms of acute as well as chronic lung disease and systemic diseases involving the lung (Table 1).505152535455565758596061 While most studies on human lung pathology focus on TGFβ1, which appears to be the predominant isoform involved in pulmonary fibrosis, increases in all three isoforms have been demonstrated.
Lefty contributes to the remodeling of extracellular matrix by inhibition of connective tissue growth factor and collagen mRNA expression and increased proteolytic activity in a fibrosarcoma model
2002, Journal of Biological ChemistryCitation Excerpt :Our findings show that lefty acts in a manner that is distinctly opposite to the effects of TGF-β on fibroblasts in vivo.For several reasons, an attractive model is one in which the in vivo actions of lefty on CTGF and collagen mRNA expression, as well as reduced accumulation and increased degradation of ECM proteins, might be mediated by inhibition of the signaling of TGF-β. First, there is a close correlation between the expression of TGF-β and the extent of fibrosis in human adenocarcinomas that exhibit central fibrosis (79). The overexpression of TGF-β in PANC-1 pancreatic carcinoma cells led to desmoplasia in experimental tumors in the pancreas of athymic mice (80).
Down-regulation of decorin, a transforming growth factor-beta modulator, is associated with scarless fetal wound healing
2001, Journal of Pediatric SurgeryCitation Excerpt :In other tissues, decorin expression also is associated with scar formation and fibrosis. Increased decorin expression has been shown in postmyocardial infarct tissue, pulmonary adenocarcinoma cells, pulmonary granulomas, hepatic cirrhosis, and gastric ulcers.17-19,24,25 These findings are similar to adult cutaneous scar formation.13,23
Negative impact of hyperglycaemia on mouse alveolar development
2018, Cell Cycle