Isoniazid with thiacetazone in the treatment of pulmonary tuberculosis in East Africa—Second investigation: Co-operative Studies in East African Hospitals and Laboratòries with the Collaboration of the East African and British Medical Research Councils*
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Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti - Mycobacterium tuberculosis activity and cytotoxicity
2010, European Journal of Medicinal ChemistryCitation Excerpt :A compound related to the HZs class that has excellent anti-TB activity is isonicotinoyl hydrazide (INH), commercially known as isoniazid [10–12]. Finally, although the anti-TB activity of dithiocarbazates is not yet reported, this class of compounds is also worth investigating, in view of their great structural similarity with TSCs and because of their good activity against some bacteria [13]. Very recently, we reported the anti-TB activity of some TSCs derived from 2-acetylpyridine and their vanadium complexes and it was observed that variation of the groups on the N(4) atom of the thiosemicarbazone moiety affected the biological action [14].
Tuberculosis in Africa: Clinical presentation and management
1997, Pharmacology and TherapeuticsThe value of in vitro drug activity and pharmacokinetics in predicting the effectiveness of antimycobacterial theraphy: A critical review
1997, American Journal of the Medical SciencesThiacetazone—avoid like poison or use with care?
1993, Transactions of the Royal Society of Tropical Medicine and HygieneThe treatment of pulmonary tuberculosis in the developing countries
1978, Transactions of the Royal Society of Tropical Medicine and Hygiene
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The report should be referred to as: East African/British Medical Research Council Second Thiacetazone Investigation (1963) Tubercle, Lond. 44, 301. Reprints may be obtained from the Tuberculosis Research Unit, M. R. C. Laboratories, Holly Hill, London, N.W. 3.