Elsevier

Tubercle

Volume 44, Issue 3, September 1963, Pages 301-333

Isoniazid with thiacetazone in the treatment of pulmonary tuberculosis in East Africa—Second investigation: Co-operative Studies in East African Hospitals and Laboratòries with the Collaboration of the East African and British Medical Research Councils*

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Summary

Various combinations of isoniazid with thiacetazone have been studied in East Africans with pulmonary tuberculosis. One study with in-patients, a second with out-patients

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    A compound related to the HZs class that has excellent anti-TB activity is isonicotinoyl hydrazide (INH), commercially known as isoniazid [10–12]. Finally, although the anti-TB activity of dithiocarbazates is not yet reported, this class of compounds is also worth investigating, in view of their great structural similarity with TSCs and because of their good activity against some bacteria [13]. Very recently, we reported the anti-TB activity of some TSCs derived from 2-acetylpyridine and their vanadium complexes and it was observed that variation of the groups on the N(4) atom of the thiosemicarbazone moiety affected the biological action [14].

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*

The report should be referred to as: East African/British Medical Research Council Second Thiacetazone Investigation (1963) Tubercle, Lond. 44, 301. Reprints may be obtained from the Tuberculosis Research Unit, M. R. C. Laboratories, Holly Hill, London, N.W. 3.

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