Original article: general thoracicLung transplantation for pulmonary vascular disease
Section snippets
Patient population
Since November of 1989, 668 patients have undergone HLT, BLT, or SLT at our combined hospitals for adults (Barnes-Jewish Hospital, St. Louis, MO) and children (St. Louis Children’s Hospital, St. Louis, MO). One hundred transplants were performed in patients with PPH or PHT associated with a congenital heart defect. The pediatric population is defined as those under the age of 18 years at the time of transplantation. The current study focuses on 55 adult and 45 pediatric patients who had 51
Patient population
One hundred consecutive patients with primary or secondary PHT associated with a congenital heart defect underwent SLT, BLT, or HLT during a 10-year period. Follow-up was complete in all patients through December 31, 2000. The average length of follow-up was 5 years. The mean age was 23.7 years with a range from 1.2 months to 54.8 years. Because all of the single lung transplants were performed in adults and the majority of the BLTs and HLTs were done in the pediatric group, the SLT group as a
Comment
This study was undertaken in order to review a large, single institution experience with transplantation for PHT. When to commit a patient to lung transplantation for pulmonary vascular disease is not necessarily a straightforward decision. In recent years, making this decision has been a moving target as a result of significant advances in medical intervention that included graded balloon dilation atrial septostomy and continuous prostacyclin infusion 3, 4, 14, 15. Further, an important
References (27)
- et al.
Single- versus double-lung transplantation for PHT
J Thorac Cardioasc Surg
(1998) - et al.
Donor lung procurementassessment and operative technique
Ann Thorac Surg
(1993) - et al.
Single lung transplantation for PHTtechnical aspects and immediate hemodynamic results
J Thorac Cardiovasc Surg
(1992) - et al.
Improved technique for bilateral lung transplantationrationale and initial experience
Ann Thorac Surg
(1990) - et al.
Pediatric and adult lung transplantation for cystic fibrosis
J Thorac Cardiovasc Surg
(1998) - et al.
Graded balloon dilation atrial septostomy in severe primary PHT
J Am Coll Cardiol
(1998) - et al.
Fate of the patient with Eisenmenger syndrome
Am J Cardiol
(1971) - et al.
The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary PHT
J Am Coll Cardiol
(1999) - et al.
The registry of the International Society for Heart and Lung Transplantationsixteenth official report –1999
J Heart Lung Transplant
(1999) - et al.
Single lung transplantation and closure of patent ductus arteriosus for Eisenmenger’s syndrome
J Thorac Cardiovasc Surg
(1990)