Original articleEffect of Pseudomonas cepacia colonization on survival and pulmonary function of cystic fibrosis patients
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2020, Gynecologie Obstetrique Fertilite et SenologieThe changing epidemiology and demography of cystic fibrosis
2017, Presse MedicaleCitation Excerpt :There has been some suggestion in the literature that females colonized with B. cepacia complex have worse outcomes than males with the same organism. Lewin et al. reported that within a year after acquisition of B. cepacia complex, 33% of women died compared to 21% of males [43]. However, when overall mortality was compared between infected men and women, no significant difference was noted.
Question 6: Is there a role for Mannose-Binding Lectin measurement in Cystic Fibrosis management?
2016, Paediatric Respiratory ReviewsCitation Excerpt :Differential binding capacities against these specific pathogens has been reported [16], however, the clinical significance of these remains unclear. Of particular note, significantly more avid binding to Burkholderia cepacia (vs. Pseudomonas) has been shown to influence initiation of the complement cascade in vitro and this is of interest given the more aggressive respiratory decline associated with Burkholderia cepacia infection in CF subjects [17]. Interestingly, Garred et al. [18] demonstrated that Burkholderia cepacia was significantly more frequent in carriers of abnormal MBL alleles, even amongst those who were heterozygotes for the abnormal allele.
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2013, Emery and Rimoin's Principles and Practice of Medical GeneticsCystic Fibrosis: What to Expect now in the Early Adult Years
2012, Paediatric Respiratory ReviewsCitation Excerpt :Outcomes related to Bcc infection in CF have been evaluated in numerous observational studies.51 Bcc infection can result in disparate clinical outcomes ranging from asymptomatic carriage to increased rate of FEV1 decline to increased pre-/post-lung transplant mortality.53–59 Clinical outcomes are heterogeneous as Bcc infection severity is likely related to a combination of microbial factors (such as extent of virulence and multi-drug resistance) and host factors (such as immune status).51